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Agilent InfinityLab Poroshell 120 columns family

Advance throughput and resolution for more analytes than ever | Agilent InfinityLab Poroshell 120 columns for HPLC and UHPLC

More than 15 years ago, Agilent introduced Poroshell 300, the first commercial columns to use superficially porous particle technology. Now, InfinityLab Poroshell 120 columns have become critical tools for solving the latest challenges in the analytical world.

Today, the InfinityLab Poroshell 120 family has grown to include 19 chemistries—including new phases for chiral and HILIC separations. Together, they deliver exceptional efficiency for HPLC and UHPLC applications, and significantly boost performance from every LC in your research lab.

Put InfinityLab Poroshell 120 innovation to work for your challenging Chiral and HILIC separations

NEW Chiral columns

NEW Chiral columns

Can we detect enantiomers quickly when time is short?

InfinityLab Poroshell 120 Chiral columns are the first columns to combine superficially porous particles with innovative chiral stationary phases to deliver:

  • Higher performance and speed, compared to totally porous chiral stationary phases
  • Poroshell 120 ruggedness and reliability
  • A wide range of chemistries and LC modes to maximize flexibility
  • Superior peak shape to effectively resolve enantiomers
  • Increased throughput with more efficient chiral separations
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Expanded HILIC columns

Expanded HILIC columns

Are we achieving the best possible separation of polar compounds?

NEW InfinityLab Poroshell 120 HILIC-Z and HILIC-OH5 phases allow you to retain and separate polar analytes using a standard LC system and reversed-phase solvents. Advantages include:

  • Innovative chemistries for superior retention of highly charged polar analytes
  • Robust, reliable Poroshell particle technology
  • Exceptional stability in harsh method conditions
  • Compatibility with MS eluents
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Unique particle technology and exceptional manufacturing quality

particle sizes

Scalable particle sizes:
get more from your methods

What makes InfinityLab Poroshell 120 columns different?

InfinityLab Poroshell 120 columns are based on superficially porous particle technology, which features a solid silica core and a porous outer layer. The benefit: higher chromatographic efficiencies and fast, high-resolution separations.

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Poroshell 120

19 chemistries:
separate nearly any compound

How do InfinityLab Poroshell 120 columns simplify method development?

With 19 different chemistries, InfinityLab Poroshell 120 columns provide a range of selectivities that makes your method development fast and easy. Plus, the alignment of InfinityLab Poroshell 120 and ZORBAX chemistries makes it easy to transfer your legacy methods.

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Quality you can count on

Quality you can count on

How can I be sure I’m getting the most reproducible columns?

All Agilent columns are designed and manufactured from start to finish by Agilent:

  • We only start with ultrapure raw materials
  • We use tightly controlled processes
  • We carry out multiple QC tests
  • We test each batch for consistency
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Complete fast, high-efficiency separations under a wide range of conditions

PH levels

High or low pH:
the choice is yours

How can I achieve high-pH stability for method development?

Incorporating Agilent hybrid particle technology, InfinityLab Poroshell HPH-C18 and HPH-C8 columns provide robust performance—including high-pH stability. So you can use the Poroshell 120 family for all your method development needs, regardless of mobile phase pH.

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Ultrafast, high-resolution separations

Ultrafast, high-resolution separations: sub-2 µm columns

How can we get the most from the instruments we have?

Agilent InfinityLab Poroshell 120 1.9 µm columns deliver long life and robustness under the most demanding conditions. They also generate lower pressures than many other sub-2 µm columns.

That means you can use high flow rates to drive ultrafast separations without exceeding the pressure rating of your UHPLC instruments.

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LC columns

LC column
navigator tool

How can I find the best column for my application?

Our LC Column Navigator Tool makes it easy to find a more efficient replacement for your current column—or get recommendations for a new column, based on method parameters.

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Make every step of your LC workflow run more smoothly


InfinityLab supplies:
superior productivity

How can we work more efficiently and achieve our throughput goals?

Agilent InfinityLab is an optimized portfolio of LC instruments, columns, and supplies that work together in perfect harmony. It’s designed to provide the highest efficiency for your LC workflow—regardless of application area.

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LC instruments

Efficient LC instrument solutions

How do we run conventional and UHPLC methods efficiently and confidently?

From routine analysis to cutting-edge research, the Agilent InfinityLab LC Series offers the broadest portfolio of LC systems for any application and budget. The family includes:

  • Agilent 1220 Infinity II LC—Affordable efficiency
  • Agilent 1260 Infinity II LC—Everyday efficiency in every way
  • Agilent 1290 Infinity II LC—The benchmark in efficiency
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Efficient LC method development

method development

How can we take the guesswork out of developing robust LC methods?

The complete Agilent InfinityLab LC Method Development Solution combines:

  • Robust InfinityLab Poroshell 120 columns
  • Modular Agilent LC systems
  • Innovative Agilent software and supplies
  • Support backed by more than 75 years of expertise
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In-depth applications advice, at your fingertips

Best LC practices

Best LC practices for efficient lab operations

This 3-part webinar series will show you how to achieve the most reliable LC results and efficient lab operations.

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UHPLC analyses

Are you getting the best value
from your UHPLC analyses?

In this webinar, discover how innovations in sub-2 µm superficially porous UHPLC columns provide the highest efficiency under UHPLC conditions.

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fruit juice analysis

Fast analysis of fruit juice
acids with an InfinityLab Poroshell
120 SB-Aq column

Explore a rapid, precise HPLC procedure for quantitative determination of organic acids in fruit juices under reversed-phase conditions.

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Beta blockers chart

Separation of beta blockers
at low and high pH using
InfinityLab Poroshell HPH C18

See how new hybrid superficially porous particle technology enables a wider pH range in pharmaceutical method development.

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EPA-8330A analysis

Improved EPA-8330A analysis
with an InfinityLab Poroshell 120,
1.9 μm column

Find out how an analysis of nitroaromatics and nitramines was improved by using a superficially porous 1.9 μm column, compared to the 5 μm column suggested by the US EPA.

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Agilent CrossLab method and application consulting

Accelerate productivity and improve outcomes

Agilent CrossLab application support can help you confidently deploy the latest productivity enhancements and ensure the best outcomes—from sample preparation to final report.

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Ready to advance your HPLC and UHPLC capabilities?

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For Research Use Only. Not for use in diagnostic procedures.