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Advance throughput and resolution for more analytes than ever

Agilent InfinityLab Poroshell 120 columns for HPLC and UHPLC

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You need to develop methods that will increase throughput, reduce cost per sample, and solve new challenges. In addition, you need to do this quickly while ensuring seamless method transfer. This requires a reproducible and scalable range of selectivities to find the optimal separation for your sample.

The Agilent InfinityLab Poroshell 120 portfolio of superficially porous particle columns for HPLC and UHPLC applications offers 19 chemistries across 3 particle sizes for fast method development and adaptable methods across instruments and labs.

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19 chemistries that separate nearly any compound

Portfolio at a glance

What makes Infinitylab Poroshell 120 columns different?

Superficially porous particle technology features a solid silica core and a porous outer layer. The benefit: higher efficiencies and fast, high-resolution separations.

  • Excellent lot-to-lot reproducibility from a proprietary, single-step porous shell process
  • Faster more accurate results from high-purity silica and advanced bonding chemistries that reduce peak tailing for superior peak shape
  • Long column life achieved from robust Poroshell particles that are stable at required pressures
  • Access the quick reference selection poster and ordering guide

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Scale up to the Fast Lane

New Agilent InfinityLab Poroshell 120 preparative LC columns

Is your purification lab compromising speed to obtain reliable research data? Agilent InfinityLab Poroshell 120 preparative LC columns let you maximize resolution while improving sample throughput. They offer:

  • Speed and efficiency for labs where resolution and throughput are key
  • Seamless scalability from sub-2 µm analytical to preparative scale
  • Excellent loadability for drug discovery work
  • Robustness and reliability with long column lifetimes

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Scalable particle sizes in superficially porous particles: get more from your methods

InfinityLab Poroshell 120 4um columns

Looking for improvement within your comfort zone?

Increase your separation efficiency by 200% over traditional 5 µm columns without having to adapt your method. A simple change of column with the same method could double efficiency, while shortening the exchanged column reduces run time by 50%.

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InfinityLab Poroshell 120 2.7 µm columns

Looking for UHPLC-like performance at HPLC pressures?

Increase your sample throughput while maintaining robustness and instrument uptime. Easily double the number of samples you analyze per day when you switch from 4 µm to 2.7 µm particle size.

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InfinityLab Poroshell 120 1.9 µm columns

Looking the very high end of high-end?

Achieve up to 20% more efficiency for your UHPLC separations compared to traditional totally porous sub-2 µm columns. Now you can reach new levels of throughput with ultrafast separations.

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Complete fast, high-efficiency separations under a wide range of conditions

Flexibility and Robustness for Basic Analytes

How can I improve peak shape for basic analytes?

This charged surface c18 phase enables excellent peak shape and loadability for basic compounds with formic acid. It also offers alternate selectivity to traditional C18 columns with high and low pH stability.

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Challenging Polar Compounds

Are we achieving the best possible separation of polar compounds?

InfinityLab Poroshell 120 HILIC-Z and HILIC-OH5 phases allow you to retain and separate polar analytes using a standard LC system and reversed-phase solvents. They provide superior retention of highly charged polar analytes with robust and reliable particle technology.

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Chiral Compounds

Can we detect enantiomers quickly when time is short?

InfinityLab Poroshell 120 chiral columns are the first columns to combine superficially porous particles with innovative chiral stationary phases. They deliver higher performance and speed compared to totally porous chiral stationary phases for increased throughput with more efficient chiral separations.

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Make every step of your LC workflow run more smoothly

LC Column Selector Tool

Now easily select the best column choice for your application based on factors such as USP designation, phase chemistry, agency methods.

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InfinityLab supplies

How can we work more efficiently and achieve our throughput goals?

The “small” parts of your workflow can make a big difference in the quality of your results. Agilent InfinityLab supplies are innovatively designed to make your daily tasks more efficient from perfect column connections, preventing solvent evaporation, and more.

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Agilent InfinityLab

Are you a champion in LC efficiency?

Reliable, efficient, always innovating for your best result. Every component of the Agilent InfinityLab LC family is uniquely designed to work together. Play our InfinityLab trivia game to see if you have what it takes to be an InfinityLab champion.

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In-depth applications advice, at your fingertips

Oh no! Not another boring webinar on column lifetime?

Are you looking for a comprehensive summary on how to protect your HPLC column from early failure, clogging and performance loss? Look no further.

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A guide to updating HPLC compendial methods in pharmaceutical analysis

Learn about the vital role of compendial methods in pharmaceutical analysis and how, by making adjustments to the, laboratory efficiency and be increased and cost decreased.

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HPLC Educational Webinar Series

Agilent application experts have delivered a large number of webinar materials all available ondemand at your convenience.

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Agilent Community

Get answers. Share insights. Build connections. The Agilent community enables you to access support resources, latest helpful content, and connect with peers.

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InfinityLab Application Finder

Browse LC application notes by system, market or publication number. This helpful tool ensures you can early find the applications you need

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Agilent CrossLab method and application consulting

Accelerate productivity and improve outcomes

Agilent CrossLab application support can help you confidently deploy the latest productivity enhancements and ensure the best outcomes—from sample preparation to final report.

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Ready to advance your HPLC and UHPLC capabilities?

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For Research Use Only. Not for use in diagnostic procedures.