Columns and Standards for Oligonucleotide HPLC Analysis
AdvanceBio oligonucleotide HPLC columns offer the robustness necessary for successful HPLC oligonucleotide analysis at high pH. AdvanceBio columns have high resolving power and are robust enough to withstand challenging conditions to successfully separate trityl-off, deprotected oligonucleotides,
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Featured Customer Testimonials
Piotr Alvarez
Senior Scientist, RIC Group
The deactivated HILIC-Z column substantially reduced the undesired analyte-surface interactions in the analysis of GLP-1 receptor agonist drug products. We observed at least a 30% increase in sensitivity and reduction in peak tailing for the analysis of acidic peptides and excipients. Peptide impurities eluting in the peak tail were hardly detectable when using conventional stainless steel hardware.