AdvanceBio SEC HPLC Columns

AdvanceBio SEC columns deliver accurate, precise quantitation for aggregate and fragment analysis of mAbs, other proteins, and peptides. These innovative size exclusion chromatography columns were designed and engineered to improve lab productivity by providing robust, reliable methods that eliminate sample re-analysis. Consistent results are achieved from column to column, batch to batch, and lab to lab, ensuring that methods can be transferred across departments and locations to put an end to uncertainty.

AdvanceBio SEC 2.7 µm columns are robust columns for routine SEC needs, with a unique hydrophilic coating to minimize secondary interactions between the sample and stationary phase without adding extra salt or organic solvent to the mobile phase. Even for sticky samples such as Antibody Drug Conjugates (ADCs), this column has minimized secondary interactions for accurate answers. Available in two pore sizes, 300 Å and 130 Å, they are ideal for sensitive, highly reproducible aggregate analysis of proteins and peptides.

AdvanceBio SEC 1.9 µm columns bring your SEC separations to the next level. The smaller particle and a hydrophilic chemistry, results in high efficiency, high resolution separations. Stability up to 620 bar enables faster flow rates for high throughput needs. The 200 Å pore size was specifically optimized for simultaneous separation of dimer, monomer, and fragment for thorough mAb characterization.