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Innovation That Drives

Peptide and protein analysis
with the new Agilent ExD cell

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Reveal more comprehensive information about complex molecules

More in-depth data about sequence, structure, modifications, and purity can help you make better decisions about your candidate molecules.

The new Agilent ExD cell with the Agilent ExDViewer analysis software easily and cost-effectively adds electron capture dissociation (ECD) to the capabilities of the 6545XT AdvanceBio LC/Q-TOF. So, you can elevate your peptide and protein analyses and minimize costly delays in your research.

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Enhance the speed and depth of your protein and peptide analyses

With its unique new hardware design, the ExD cell greatly increases fragmentation efficiency while retaining the simple operation, throughput, and reliability you’ve come to expect from Agilent LC/MS systems.

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Agilent 6545XT AdvanceBio LC/Q-TOF system

Agilent 6545XT AdvanceBio LC/Q-TOF system

Learn how the ExD cell, when added to the 6545XT, enables ECD for peptides and proteins as an alternative to collision induced dissociation (CID).

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Enhance the depth of your protein and peptide analyses

  • ExD cell
  • 6545XT AdvanceBio LC/Q-TOF
  • MassHunter BioConfirm
  • ExDViewer
Agilent ExD cell

Open a world of application possibilities

The Agilent ExD cell is ideal for analytes that are difficult to unambiguously characterize with traditional collision induced dissociation (CID) methods alone.

  • Maximize confidence in your conclusions. High fragmentation efficiency empowers users to gain information from difficult samples.
  • Perform top- or middle-down characterization. Synergy with the 6545XT makes the system well suited for characterization of larger proteins.
  • Make faster, more informed decisions. Microdroplet reactions in the Agilent Jet Stream ion source enable real-time flash characterization.
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Agilent 6545XT AdvanceBio LC/Q-TOF

Handle multiple characterization workflows

When you need to access intact protein information, confirm a sequence through peptide mapping, or understand post-translational modifications, the Agilent 6545XT AdvanceBio LC/Q-TOF is your cornerstone system.

  • Accurately profile major and minor proteoforms with highly sensitive time-of-flight technology.
  • Dig deeper into peptide digests with the iterative MS/MS mode of operation.
  • Be sure of your results with mass accuracies within 10 ppm for glycosylated intact proteins.
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Agilent MassHunter BioConfirm software

Confidently analyze for major CQAs

Agilent MassHunter BioConfirm software enables routine biomolecule characterization through easy-to-use workflows for oligonucleotide analysis, intact protein analysis, peptide mapping, and routine glycan profiling.

  • Minimize security risks and preserve data integrity with advanced security features and built-in technical controls.
  • Tools like the drug-to-antibody ratio calculator, flexible report templates, and integrated operation with Agilent MassHunter WalkUp bring expert LC/MS capabilities to nonexperts.
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Accelerate top-down analysis

The Agilent ExDViewer analysis software allows you to interpret information-rich top-down MS/MS spectra quickly, accurately, and intuitively, improving confidence in your conclusions.

  • Simplify spectra: Deconvolute isotopically-resolved ions with speed and certainty.
  • Interpret ECD, CID, and more: Assign protein backbone and satellite ion types: b, y, c, z, a, x, d, w.
  • Identify structure from spectra: Define custom protein sequences, fixed and variable modifications, and amino acid building blocks. Look for evidence of variants with open modification search.
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Ready to add ECD to your workflows? We can help.

Let us show you how the Agilent ExD cell can advance your research by providing a more illuminating approach to analyzing proteins and peptides.

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