6545XT AdvanceBio LC/Q-TOF
6545XT AdvanceBio LC/Q-TOF
Accurately profile major and minor proteoforms with time-of-flight technology, offering new levels of sensitivity and clarity to intact protein mass spectrometry. Easily dig deeper into peptide digests with the Iterative MS/MS mode of operation. The 6545XT AdvanceBio Q-TOF is the analytical cornerstone in a comprehensive set of tools designed for biopharma.
- Quadrupole Time of Flight LC/MS
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Product Details
- Get up and running fast with quick-start methods that include Agilent AdvanceBio LC columns for intact protein and peptide workflows
- Characterize both major and minor intact protein variations with an automated data workflow featuring MassHunter BioConfirm software
- Adapt your instrument to your needs with SWARM autotune to ensure optimum performance with no manual adjustment
- Large molecule tune option provides sub-nanogram detection levels for intact glycosylated monoclonal antibodies
- Be sure of your results with mass accuracies within 10 ppm for glycosylated intact proteins
- Dig deeper into your digested samples with the powerful iterative MS/MS feature
- Maximize your uptime with a system tested to perform through thousands of protein injections without degradation of performance
- Minimize maintenance delays with vent-free cleaning of entrance optics
- Integration of either MOBILion Systems’ MOBIE or e-MSion’s ExD cell is supported
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| MS Mass Accuracy (positive) |
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| MS/MS Mass Accuracy (negative) |
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| MS/MS Mass Accuracy (positive) |
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| Quad Resolution (FWHM) |
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| Quadrupole Isolation Mass Range |
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| Supported Software Add-Ons |
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| TOF Mass Range |
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| TOF Mass Resolution (FWHM) |
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| Ventless Maintenance |
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Additional Technology and Software Capabilities for LC/Q-TOF
Agilent partners with selected companies who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF!
Learn More- Key Literature
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Flash Characterization of Antibodies via Microdroplet Reactions in an Unmodified Jet Stream Source
This application note demonstrates in-source reaction of mAb's for flash characterization on an Agilent 6545XT AdvanceBio LC/Q-TOF.
- Application Notes
- English
- 12 Oct 2023
- 1.95 MB
Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF
This application note demonstrates an oligonucleotide sequence confirmation workflow using Agilent BioConfirm software with an Agilent 1290 Infinity II LC and Agilent 6545XT AdvanceBio LC/Q-TOF.
- Application Notes
- English
- 02 Aug 2022
- 2.40 MB
- Application Notes
- Brochures
- Flyers
- Posters
- Technical Overviews
- White Papers
Agilent Announces New Oligonucleotide Analysis Software for Biopharma Research
Agilent MassHunter BioConfirm 12.0 software introduces enhancements to existing capabilities for protein analysis and adds support for ligonucleotide analysis. The addition of oligonucleotide support significantly extends the capabilities of MassHunter BioConfirm, adding critical functionality for assessing oligonucleotide purity and sequence confirmation – important analytical steps in the use of oligonucleotides for biotherapeutics and vaccine research and development.
- 05 Jun 2022
Agilent Announces Inspirational LC/TQ and LC/Q-TOF Mass Spectrometry Solutions at ASMS 2023
Agilent Technologies announced two new liquid chromatography mass spectrometry systems (LCMS), the Agilent 6495D LC/TQ and the Agilent Revident LC/Q-TOF. Facilitating the high-end performance of the Revident LC/Q-TOF, Agilent is also announcing the new Agilent MassHunter Explorer Profiling software and the new Agilent ChemVista library manager software.
- 05 Jun 2023
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Agilent University
Develop skills and improve lab productivity with a wide variety of learning options from Agilent Education.
- Support
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MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use your MassHunter Data Acquisition for Agilent LC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: • Workstation (standalone, no content management) • Networked Workstation (networked, with content management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
MassHunter Networked Workstation Functional Design Specifications
This document contains the Functional Design Specifications for your Agilent MassHunter Networked Workstation system.
- Specifications
- English
- 17 Nov 2022
- 13.06 MB
- FAQs
- Quick Reference Guides
- Site Preparation Checklists
- Supplemental Information
- User Manuals