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Doctor Steven Gross

Defining Signal Pathways


At the forefront of biological nitric oxide research

In partnership with Agilent Technologies, Dr. Steven Gross of Weill Cornell Medical College is investigating nitric oxide (NO) related diseases, therapies, and biomedical problems.

NO is a critical cellular signaling molecule that impacts a variety of processes, including blood pressure, neuronal signaling, and host defense. Dr. Gross is working toward defining NO signal pathways to enable the development of therapies for related diseases, and is applying metabolomics approaches to address biomedical problems. This research is leading to the identification of novel molecular mechanisms and targets, and a greater understanding of NO synthesis and action in cells, including the effects of ancillary genes.

 Steven Gross, Ph.D.

Professor of Pharmacology
Director, Mass Spectrometry Core Facility
Weill Cornell Medical College
New York, NY

Selected publications

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.
Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE.
Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0.

Reversible methylation of m6Am in the 5' cap controls mRNA stability.
Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR.
Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022

Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Akimova D, Wlodarczyk BJ, Lin Y, Ross ME, Finnell RH, Chen Q, Gross SS.
Birth Defects Res. 2017 Jan 30;109(2):106-119

Metabolomics enables precision medicine: "A White Paper, Community Perspective".
Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative.
Metabolomics. 2016;12(10):149

Untargeted metabolite profiling reveals that nitric oxide bioynthesis is an endogenous modulator of carotenoid biosynthesis in Deinococcus radiodurans and is required for extreme ionizing radiation resistance.
Hansler A, Chen Q, Ma Y, Gross SS.
Arch Biochem Biophys. 2016 Jan 1;589:38-52. doi: 10.1016/j.abb.2015.10.010.

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