6545XT AdvanceBio LC/Q-TOF
6545XT AdvanceBio LC/Q-TOF
利用飞行时间技术准确分析主要和次要蛋白质形式，提供了全新水平的灵敏度和更清晰的完整蛋白质质谱。采用迭代 MS /MS 操作模式轻松深入分析多肽酶解物。6545XT AdvanceBio Q-TOF 是为生物制药设计的全套工具的重要组成部分。
- Quadrupole Time of Flight LC/MS
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Product Details
- 用快速启动方法快速启动和运行，该方法包括用于完整蛋白质和多肽工作流程的 Agilent AdvanceBio 液相色谱柱
- 通过采用 MassHunter BioConfirm 软件的自动化数据工作流程表征主要和次要完整蛋白变异
- 利用粒子化群调 (SWARM autotune) 功能根据您的需要调整仪器，确保获得出色性能，无需手动调节
- 大分子调谐选项为完整糖基化单克隆抗体提供了亚纳克级检测限
- 糖基化完整蛋白质的质量准确度在 10 ppm 以内，让您的结果更加可信
- 通过强大的迭代 MS/MS 功能深入研究消解样品
- 久经验证的系统在执行数千次蛋白质进样后性能无明显下降，大大延长正常运行时间
- 进样口清洁无需放空，可大大缩短维护时间
- 支持 MOBILion Systems 的 MOBIE 或 e-MSion 的 ExD 池的集成
| MS 灵敏度（正离子） |
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| MS 质量准确度（正离子） |
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| MS 质量准确度（负离子） |
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| MS 采集速率 |
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| MS/MS 灵敏度（正离子） |
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| MS/MS 质量准确度（正离子） |
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| MS/MS 质量准确度（负离子） |
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| MS/MS 采集速率 |
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| TOF 质量分辨率 (FWHM) |
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| TOF 质量范围 |
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| 四极杆分离质量范围 |
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| 四极杆分辨率 (FWHM) |
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| 支持的附加软件 |
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| 无需放真空的维护 |
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| 极性切换占空比 |
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| 温度质量稳定性 |
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| 离子源 |
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| 谱图内动态范围 |
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| 软件平台 |
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- Application Notes
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Differentiation of Isomeric Amino Acids by Electron Capture Dissociation
Agilent 6545XT AdvanceBio LC/Q-TOF equipped with an ExD cell was used to differentiate isomeric amino acids in a tryptic peptide.
- Application Notes
- English
- 21 May 2026
- 835.33 KB
Authenticity Evaluation of Insect Protein-Containing Food Products
This note presents an LC/MS workflow for the taxonomic authentication of insect-derived ingredients in commercial cricket-based protein bars.
- Application Notes
- English
- 13 Apr 2026
- 773.90 KB
Top-Down Sequence Analysis of Intact Proteins Using an Agilent AdvanceBio 6545XT LC/Q-TOF with ExD
This application note describes a method for top-down fragmentation using the Agilent 6545XT AdvanceBio LC/Q-TOF with an electron capture dissociation (ExD) cell.
- Application Notes
- English
- 07 Jan 2026
- 790.03 KB
Streamlined Workflows for N-Glycan Analysis of Biotherapeutics with LC/FLD/MS
Streamlined workflows for N-Glycan analysis of biotherapeutics using Agilent AdvanceBio Gly-X InstantPC and 2-AB Express sample preparation with LC/FLD/MS
- Application Notes
- English
- 11 Mar 2025
- 1.19 MB
Analysis of Degradation Impurities of Glucagon-Like Peptide-1 Agonists by LC/Q-TOF MS
Characterization of forced degradation impurities of glucagon-like peptide-1 agonists by Agilent LC/Q-TOF mass spectrometry.
- Application Notes
- English
- 15 Jan 2025
- 837.39 KB
A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS
A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS
- Application Notes
- English
- 25 Oct 2024
- 1.15 MB
LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab
The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
- Application Notes
- English
- 25 Oct 2024
- 1.59 MB
Automated Monoclonal Antibody Subunit Analysis by Online Reduction Using 2D-LC/MS
This application note describes an automated 2D-LC workflow for the reduction of mAbs using Protein A affinity chromatography in the first dimension and MS-compatible size exclusion chromatography (SEC) in the second dimension.
- Application Notes
- English
- 14 Oct 2024
- 756.97 KB
LC/MS Based Characterization of GLP-1 Therapeutic Peptide Liraglutide and Impurities
LC/MS based characterization workflow of the GLP-1 therapeutic peptide liraglutide and its impurities using the 1290 Infinity II LC and 6545XT AdvanceBio LC/Q-TOF.
- Application Notes
- English
- 26 Sep 2024
- 2.78 MB
Analysis of Lipid Nanoparticle Components Using Agilent 6545XT AdvanceBio LC/Q-TOF
This application note proposes an LC/MS method for the analysis of lipid components of mRNA encapsulated in lipid nanoparticles using the 6545XT AdvanceBio LC/Q-TOF.
- Application Notes
- English
- 03 Jun 2024
- 466.49 KB
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安捷伦在 ASMS 2024 年会上隆重推出运用前沿 GC/MS 和 LC/Q-TOF 技术的新产品
安捷伦推出两款新产品。Agilent 7010D 三重四极杆气质联用系统 (7010D GC/TQ) 配备全新的 HES 2.0 离子源，灵敏度可达阿克级，稳定性无出其右，仪器正常运行时间居于行业前列。适用于 6545XT AdvanceBio LC/Q-TOF 的 Agilent ExD Cell 可增加电子捕获解离 (ECD) 功能，助力多肽和蛋白质表征。
- 06 Jun 2024
Videos
- Support
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MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use your MassHunter Data Acquisition for Agilent LC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: • Workstation (standalone, no content management) • Networked Workstation (networked, with content management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
GC/MS and LC/MS MassHunter Workstation and Networked Workstation Requirements Guide
This document details the minimum computer hardware, software, and network requirements as well as the minimum instrument firmware revisions required to run an Agilent MassHunter Workstation or Agilent MassHunter Networked Workstation. Also included are the supported instrument types and Windows operating system configurations.
- Site Preparation Checklists
- English
- 12 Nov 2025
- 1.18 MB
- FAQs
- Quick Reference Guides
- Site Preparation Checklists
- Supplemental Information
- User Manuals