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What do rates of change in oxygen consumption and extracellular acidification tell me about my cells?

Observing the interplay between the two major energy-producing pathways of the cell reveals the metabolic phenotype and how it responds to substrates, stress, or pathological conditions. Studying the system's capacity to meet changing energy demands enables researchers to connect physiological traits of cells with genomic and proteomic data to generate new insights into obesity, diabetes, cancer, cardiovascular and neurodegenerative function and safety toxicity.