Exploring the Role of Metabolism in Immune Function
Whether the research focus is on a specific immune cell type, signaling pathway, or substrate usage, immunologists are actively exploring the mechanisms that drive and perpetuate antigen recognition and response. Immunometabolism has emerged as a crucial component to understand the connection between metabolic pathways and immune responses. Agilent Cell Analysis technology is at the forefront, providing powerful and effective tools to explore this burgeoning field of research.
In this webinar, Dr. David Ferrick discusses how advances in our understanding of T cell co-receptors have led to new strategies for keeping immune cells turned on in the suppressive, hostile tumor microenvironment. Much has been learned in the last decade about metabolic reprogramming in cancer, focused initially on tumor metabolism. However, by applying this knowledge to infiltrating immune cells we are now beginning to appreciate the metabolic drivers of immune cell fitness, specifically stable mitochondrial function that can perhaps reverse exhaustion phenotypes by enhancing survival and function in hypoxic and nutritionally depleted tumor microenvironments.
This tutorial describes a novel assay that measures immune cell activation from within minutes of activation throughout the fully developed activated phenotype in both a qualitative and quantitative manner. This provides a sensitive window of opportunity to identify and characterize attributes that can drive immune responses to desired outcomes.
Join us for our eSeminar presented by Dr. Ping-Chih Ho to learn about Agilent Cell Analysis applications in cancer immunotherapy research.
The aberrant accumulation of regulatory T cells (Tregs) in tumors promotes immunosuppressive features of the tumor microenvironment (TME). Although depleting Tregs unleashes antitumor immunity and reprograms the immune status of the TME, the therapeutic potential of Treg-targeting is largely compromised due to autoimmunity induced by systemic loss of Tregs. Given that Tregs reside in different locations where they contain distinct nutrient composition, metabolic adaptation should be engaged by Tregs to support their tissue retention and tissue-dependent behavior. This talk will discuss how we can selectively demolish intramural Tregs by targeting unique metabolic preference of intratumoral Tregs and how this approach can be utilized for cancer research.