
Aging Research
Applying Functional Metabolism to Aging Research
There is a well-defined relationship between mitochondrial dysfunction and age-related diseases, including Alzheimer’s disease, Parkinson's disease, amongst others. With an increasing aging population, research into associated diseases are key to enhancing scientific understanding. Using Agilent Seahorse XF technology, researchers are now able to employ a variety of cell types and model organisms to test, analyze, and reveal unique insights into this field of research.
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For Research Use Only. Not for use in diagnostic procedures.
Assessing functional metabolism using cells sourced from blood
- PDF/ FOUND IN: APPLICATION NOTES
- Date : 04 Jan 2017
- FILE SIZE : 643.12 KB
Agilent Cell Analysis Webinar Series
Find upcoming Agilent Cell Analysis Technology webinars and view recordings of past webinars on key topics in cell metabolism research and bioenergetics.
Biochemical analysis in C. elegans as a model for metabolic disease and aging
The nematode C. elegans has been used as a model for aging because of its limited lifespan and excellent genetic tools. Additional biochemical tools, however, are thinly spread, precluding full physiological work-up. Using diverse genetic models, including the caloric restriction mutant eat-2, the mitochondrial mutants mev-1 (succinate dehydrogenase) and cco-1 (cytochrome c oxidase), and pharmacological interventions, we established a variety of biochemical assays to complement lifespan analysis. These include the measurement of NAD+, mitochondrial respiration, oxidative stress, and mitochondrial morphology.
Tutorial: Measuring Bioenergetics in a Variety of Cell Types
Recent discoveries have linked mitochondrial dysfunction and defects in cellular bioenergetics to the pathophysiology of many diseases including obesity, diabetes, cancer, cardiomyopathy and neurodegeneration. The introduction of Extracellular Flux (XF) technology has enabled non-invasive, real time profiling of cellular bioenergetics and mitochondrial function in living cells, opening a new window to study these diseases.
- Application Notes
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Assessing functional metabolism using cells sourced from blood
Real-time, kinetic measurements of functional metabolism in cells sourced from blood link mitochondrial function to disease diagnosis and progression.
- Application Notes
- English
- 04 Jan 2017
- 643.12 KB
Measure Mitochondrial Respiration in Skeletal Muscle Fibers with a Seahorse Analyzer
Measuring Mitochondrial Respiration in Intact Skeletal Muscle Fibers with an Agilent Seahorse XF24/XFe24 Analyzer
- Application Notes
- English
- 22 Dec 2016
- 1.07 MB
Energy Pathways Video
- 00:02:06