Mitochondrial Disease Research

Determining Mitochondrial Gene Mutation Phenotypes

Mitochondrial diseases are a defined group of disorders that are a result of a dysfunctional mitochondrial respiratory chain. Genetic mutations are the cause of numerous metabolic diseases and disorders, including both rare and well-documented. This group of diseases can affect a single organ, as well as multiple organ systems. Researchers are using Agilent Cell Analysis technology to gain unique and powerful insights into these diseases.

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Click to search either the Agilent Cell Analysis Publications Database or the Cell Reference Database

For Research Use Only. Not for use in diagnostic procedures.

Training & Events

Agilent Cell Analysis Webinar Series

Find upcoming Agilent Cell Analysis Technology webinars and view recordings of past webinars on key topics in cell metabolism research and bioenergetics.

eSeminar/Training

Bioenergetic Evaluation in Mitochondrial Disorders

Traditional, spectrophotometric assays that measure the activity of individual respiratory complexes in tissue samples are limited by their sensitivity and the availability of sufficient biological material for testing. XF Bioenergetic Assays with patient fibroblast cultures overcome this limitation and have the advantages of being less affected by tissue specificity and the attenuation of defects detected spectrophotometrically in muscle or liver that disappear in cultured fibroblasts.

eSeminar/Training

Tutorial: Measuring Bioenergetics in a Variety of Cell Types

Recent discoveries have linked mitochondrial dysfunction and defects in cellular bioenergetics to the pathophysiology of many diseases including obesity, diabetes, cancer, cardiomyopathy and neurodegeneration. The introduction of Extracellular Flux (XF) technology has enabled non-invasive, real time profiling of cellular bioenergetics and mitochondrial function in living cells, opening a new window to study these diseases.

eSeminar/Training

Mitochondrial Disease Research

Determining Mitochondrial Gene Mutation Phenotypes

Cell-Based Screening for Drug-Induced Mitochondrial Toxicity

Cell-Based Screening for Drug-Induced Mitochondrial Toxicity

Agilent Cell Analysis Webinar Series

Find upcoming Agilent Cell Analysis Technology webinars and view recordings of past webinars on key topics in cell metabolism research and bioenergetics.

Bioenergetic Evaluation in Mitochondrial Disorders

Tutorial: Measuring Bioenergetics in a Variety of Cell Types

Energy Pathways Video

Measuring Cell Metabolism - Transient Micro-chamber Video