Drug Discovery
Validate your metabolic targets and assess mitochondrial liability with energy metabolism
Metabolic pathway dysregulation is observed in many different pathological states including cancer, cardiovascular, and neurodegenerative diseases as well as obesity and diabetes. This means if you’re not considering energy metabolism in your target identification and validation studies, you could be missing important targets. Once compounds are in hand, assessing their mitochondrial toxicity in cells can reduce risk of adverse events later in the development process. Agilent cell metabolism platforms analyze live cells in real time so you can be sure that your targets and compounds are worth pursuing.
Which cell metabolism analysis platform is right for you?
For Research Use Only. Not for use in diagnostic procedures.
Cell-Based Screening for Drug-Induced Mitochondrial Toxicity
- PDF/ Found In: Application Notes
- Date : 08 Jan 2020
- File Size : 871.66 KB
Targeting Energy Metabolism for Cancer Therapeutic Discovery using Agilent Seahorse XF Technology
- PDF/ Found In: Application Notes
- Date : 12 Jun 2019
- File Size : 503.32 KB
Direct Measurements of Cellular Metabolism for Identification of Mitochondrial Drug Targets
- PDF/ Found In: Application Notes
- Date : 10 Jun 2019
- File Size : 389.41 KB
- Application Notes
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Cell-Based Screening for Drug-Induced Mitochondrial Toxicity
A demonstration of the performance of the Agilent MitoXpress Xtra oxygen consumption assay for identifying drug induced mitocondrial toxicity.
- Application Notes
- English
- 08 Jan 2020
- 871.66 KB
Targeting Energy Metabolism for Cancer Therapeutic Discovery using Agilent Seahorse XF Technology
Measuring bioenergetic phenotype, cellular ATP production rates, and mitochondrial and glycolytic function with Agilent Seahorse XF technology can reveal metabolic vulnerabilities in cancer cells to advance cancer therapeutics.
- Application Notes
- English
- 12 Jun 2019
- 503.32 KB
Direct Measurements of Cellular Metabolism for Identification of Mitochondrial Drug Targets
An overview of how the Agilent Seahorse XF Cell Mito Stress Test and XF PMP workflows can be applied to mitochondrial and metabolic target identification studies.
- Application Notes
- English
- 10 Jun 2019
- 389.41 KB
Measuring Microbial Metabolism
Correlating Microbial Proliferation with Antibiotic Resistance using the MitoXpress Xtra Oxygen Consumption Assay
- Application Notes
- English
- 25 Feb 2019
- 489.30 KB
Agilent LC/MSD XT Single Quadrupole Open Access System for Synthetic Chemists
Using the Agilent LC/MSD XT in open access mode provides tremendous user flexibility to automate compound confirmation and purity/impurity analysis
- Application Notes
- English
- 14 Jun 2017
- 2.08 MB
Ultra High Speed and High Resolution Separations of Reduced and Intact Monoclonal Antibodies with Agilent ZORBAX RRHD Sub-2 μm 300 Diphenyl UHPLC Column
JM
- Application Notes
- English
- 23 Sep 2012
- 806.90 KB
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