Neuronal cells are characterized by high energy demand and are highly dependent on mitochondrial function for survival. Mitochondrial dysfunction is a common cause of neurodegenerative disease, with mitochondrial respiration and oxidative phosphorylation serving as a sensitive indicator of diseases including:
As well as being an indicator for neurotoxicity and the validation of disease models. Real-time metabolic measurements provide insights into processes and intermediates critical to cellular homeostasis and can deliver insights into potential drug targets for neurodegenerative disease.
The Agilent Seahorse XF platform delivers functional kinetic measurements of two key metabolic pathways, glycolysis and oxidative phosphorylation, from live cells in real time providing a sensitive and early indicator for neuronal research. The Seahorse XF platform offers researchers the flexibility to customize experiments to target their specific questions or to use Agilent Seahorse XF kits and assays for turnkey solutions in a simplified workflow.
For Research Use Only. Not for use in diagnostic procedures.
Tune in to our on-demand eSminar, with Dr. Heather Mortiboys from the University of Sheffield. In the seminar, Dr Mortiboys discusses the link between bioenergetics and neurodegeneration in translational research for therapeutic discovery, and metabolic abnormalities associated with neurodegenerative diseases including Parkinson’s and Alzheimer’s disease.
In this webinar, Dr. Scott Allen discusses how understanding the effect of the disease on catabolic pathways that influence energy generation leads to an in-depth awareness of how ALS affects energy supply in the central nervous system.
Discover how glycolytic suppression impacts neuronal stem cell differentiation, and how metabolic modulation enables improved differentiation protocols.
This application note reviews publications that use Agilent Seahorse XF technology to quantify the changes in neuronal cell metabolism, which allows researchers to understand the pathophysiology of neuroimmune and neuropsychiatric disorder.
In this webinar, Dr. Ryann Fame from Harvard Medical School and the Boston Children’s Hospital discusses how the brain fluid environment supports the health of neural stem cells of the developing brain.
Learn about a robust metabolic profiling assay system for detecting changes in mitochondrial function in disease-relevant iPSC-derived neural models.
Confirm the loss and gain of pluripotency and lineage commitment in stem cell disease models using real-time metabolic measurements to gain confidence in your disease models and improve protocol efficiency.
