Bioenergetics is a critical driver of immune cell function
Discover insights into immune cell processes including activation, proliferation and memory development through functional real-time metabolic measurements
Host-Pathogen Metabolism
HOST-PATHOGEN METABOLISM
Pathogens commonly target host cellular metabolic pathways to establish optimal conditions for infection. The host response may include large-scale alterations in cellular metabolism, including hijacking central carbon metabolic pathways and changing mitochondrial function. A cascade of signaling networks and checkpoints also trigger the innate immune response for combating infection.
Therapeutic intervention requires an understanding of the upstream drivers and a systems-level view of host cellular response
Agilent Seahorse XF technology provides functional kinetic metabolic measurements of the host-pathogen response for a more direct measure of cellular processes as they happen, in real time. XF measurements provide a comprehensive, systems-level view of the host-pathogen response, revealing insights into pathways and targets for therapeutic intervention.
For Research Use Only. Not for use in diagnostic procedures.
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Targeting Host Metabolism in Respiratory Viral Infections
In this webinar, Dr. Heather Smallwood discusses host metabolic reprogramming by respiratory viruses, and how targeting the host for may be one way to circumvent common issues with vaccine and therapeutic development.
Viral Hijacking of Cellular Metabolism
In this webinar, Dr. Peter Mullen discusses his research using Agilent Seahorse XF technology to reveal host response, mechanisms of viral invasion, and into potential therapeutic targets.
Respiratory Syncytial Virus Affects Host Metabolism
Discover host-pathogen effects of respiratory syncytial virus infection and therapeutic modulation of host central carbon metabolic pathways
Host T Cell Metabolism and Influenza Infection
Learn how Agilent Seahorse XF measurements reveal deeper insights into how regulating CD8+ T cells protects against influenza virus infection
Metabolic Measurements Support Norovirus Research
Explore how the Agilent Seahorse Real-Time ATP Rate Assay reveals insights into host macrophage response to norovirus infection
Additional Resources
- View Agilent Cell Analysis webinars on-demand page to discover applications in infectious disease research
- Visit the Agilent Cell Analysis Publications Database to search for publications relevant to your research
- Direct Measurements of Cellular Metabolism for Identification of Mitochondrial Drug Targets
- Discover the Drivers of Cell Fate, Function, and Fitness
- Measuring glycolytic function in cells
- Metabolic Discovery Platform: Seahorse XF Analyzer with Bravo Liquid Handler
- Target Identification and Validation Publications Guide
- Seahorse XF Glycolytic Rate Assay- A precise measure of glycolytic rate in live cells