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Biological Characterization

Get the Mass Accuracy, Specificity, and Sensitivity You Need

Confirmation of intact protein mass, major glycoforms, and other post-translational modifications (PTMs) are all critical measurements for characterizing therapeutic proteins and understanding their efficacy and stability. Mass spectrometry systems from Agilent enable all of these measurements on a single platform with high mass accuracy, specificity, and sensitivity. Widely used in the biopharmaceutical industry, mass spectrometry (often used in tandem with liquid chromatography) enables you to confirm the molecular weight of a therapeutic protein. The accurate mass measurement helps to determine whether the correct protein sequence has been expressed with the expected PTMs. It also reveals the relative abundance of different proteins or PTMs present in the same sample. Agilent offers several highly accurate solutions for measuring intact protein mass and common PTMs, including accurate-mass time-of-flight LC/MS systems and accurate-mass quadrupole time-of-flight LC/MS systems