Monoclonal antibody (mAb) drugs are challenging to analyze due to their high molecular weight. Intact protein analysis lets you rapidly measure the molecular weight of a mAb product. It also enables you to determine mAb heterogeneity—such as post-translational modifications (PTMs), antibody drug conjugates (ADCs), sequence variations, or degradation products.
Click each icon to learn how Agilent can help at every step of your intact protein analysis workflow.
The Agilent AssayMAP Bravo liquid handling system automates complex sample preparation. Its robotic precision improves reproducibility across users and labs. What’s more, it allows users to scale experiments up and down from one or two samples to tens or hundreds. Other advantages include:
Agilent PLRP-S columns are inherently hydrophobic, and provide a reproducible material that is free from silanols and heavy metal ions. Their macroporous polymer particles deliver HPLC separations over the widest pH range.
Advanced data mining and processing tools in the Agilent MassHunter software suite help you quickly and accurately extract all available information from your samples. What’s more, BioConfirm software can identify and confirm variants before you start expensive testing.
MassHunter WalkUp transforms mass spectrometry from a limited-access service into a tool that anyone can use.
Agilent CrossLab supports Agilent and select non-Agilent instruments. Our experts provide consultative support for workflow enablement, lab analytics, compliance, inventory management, and asset management, including relocation services.
Everything you need to streamline your intact protein analysis
Looking for detailed information on new techniques or technologies? Our wide range of application notes, videos, on-demand webinars, and other resources can help you achieve more accurate, reproducible results.