When Profiling Intact Glycoforms And Released Glycans, You Need To Be Agilent Sure
You can count on innovative Agilent techniques and technologies to help you perform faster glycan analysis without sacrificing data quality or spectral resolution.
Many of today’s blockbuster drugs are proteins called monoclonal antibodies (mAbs). Because glycans present on protein surfaces can affect drug functionality, you must carefully analyze the glycan profile of every protein batch during every manufacturing stage.
You can perform this analysis using two analytical methods:
Monitoring glycoforms at the intact and subunit protein level allows fast, efficient screening for major glycan content
Releasing N-glycans, followed by fluorescence labeling, gives the best quantitation, and allows detailed glycan structure identification by mass spectrometry
Click each icon to learn how to be Agilent sure at every step of your glycans workflow.
The Agilent AssayMAP Bravo liquid handling system automates complex sample preparation for glycan analysis by integrating with Prozyme GlykoPrep® kits. Its robotic precision improves reproducibility across users and labs. What’s more, it allows users to scale experiments up and down from one or two samples to tens or hundreds. Other advantages include:
The AdvanceBio 6545XT LC/Q-TOF pushes your protein analysis to new levels of performance and reproducibility. Its autotune feature allows you to optimize the system for large proteins or small labile structures, such as glycans.
Advanced data mining and processing tools in the Agilent MassHunter Software suite help you quickly and accurately extract all available information from your samples. What’s more, BioConfirm software can identify and confirm PTMs before you start expensive testing.
Agilent CrossLab service plans care for your entire laboratory with rapid onsite support, multivendor instrument service, remote instrument diagnostics, and more. From maintenance and repairs… to compliance… to relocation… our expert engineers provide insights that can improve efficiency for one instrument, or an entire lab.
Everything you need to streamline glycans analysis
Looking for detailed information on new techniques or technologies? Our wide range of application notes, videos, on-demand webinars, and other resources can help you achieve more accurate, reproducible results.
Automating Mass Spectrometry Based Glycan Identification from Sample Prep to Data Analysis
Fast, high-resolution and reproducible glycan identification is now possible. Learn more about how mAb glycosylation can be monitored at the intact, subunit, and released glycan levels in this essential webinar led by expert scientists.