Captiva EMR–Lipid provides highly selective and efficient lipid/matrix removal without unwanted analyte loss. The novel EMR-Lipid technology removes lipids based on a combination of size exclusion and hydrophobic interaction. Effective lipid removal assures minimal ion suppression of target analytes, which significantly improves method reliability and ruggedness. The 96-well plate and 1 mL cartridge formats contain a solvent retention frit, which allows solvent-first in-well protein precipitation which streamlines sample preparation. The improved filter design gives easy flow with vacuum or positive pressure. The 3 and 6 mL cartridge formats allow gravity flow with the absence of solvent retention frits and are easy to use.