
The TRS100 quantitative pharmaceutical analysis system
TRS100 Quantitative Pharmaceutical Analysis System
A TRS100 system can reduce content uniformity, assay, and ID tests to minutes per batch, saving significant cost and speeding up your quality control workflow. Sample preparation and consumables are not needed, meaning skilled analytical resources are not required. Content uniformity testing methods using transmission Raman have been approved by regulators using ICH and regulatory authority-acceptable protocols.
- Raman Pharmaceutical Analysis Systems
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Product Details
- Assay hundreds of tablets or capsules in minutes
- Works with intact capsules and coated tablets of most thicknesses
- No sample preparation, wet chemistry, or skilled testing resources needed
- Quantifies APIs and excipients in a single measurement
- Limit of quantification as low as 0.1% w/w
- Quantifies polymorphs in intact tablets
- Lean calibration models—easy to build and maintain
- Methods approved by regulators
- A range of sample trays and accessories for tablets, capsules, liquids, and powders are available
- Built-in technical controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11 and EU Annex 11 regulations
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- Key Literature
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Implementing Transmission Raman Spectroscopy for Fast Content Uniformity Testing: From Feasibility Evaluation to a Validated Release Method
Dr. Meike Romer discusses why transmission Raman spectroscopy is ideal for content uniformity, how it works in conjunction with established liquid chromatography (LC) methods, and the approach that led to the implementation of TRS systems for content uniformity testing at Grünenthal Pharma.
- White Papers
- English
- 30 Mar 2021
- 1.46 MB
Quantitative Determination of Salt-Form Impurities of Warfarin at the Lowest Commercial Dose Strength using Transmission Raman Spectroscopy
An analysis and quantification of Warfarin sodium salts in intact tablets at low doses.
- Application Notes
- English
- 20 May 2019
- 1.66 MB
Quantification of Tablets Containing Multiple APIs Using Transmission Raman
The quantification of three active pharmaceutical ingredients and 2 excipients using a 9 second transmission Raman spectroscopy measurement
- Application Notes
- English
- 22 Jan 2018
- 788.16 KB
- Application Notes
- Brochures
- Flyers
- Primers
- White Papers
- FAQs
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TRS100 & Transmission Raman FAQs
FAQs on content uniformity, polymorph and crystallinity analysis using transmission Raman spectroscopy (TRS) and the Agilent TRS100. Explore the fundamentals of TRS technology, method development, pharma QC cost saving, product compatibility, the regulatory landscape, and more.
What is Raman Spectroscopy? FAQ Guide
Learn about Raman spectroscopy—FAQs such as what is Raman spectroscopy, how does Raman spectroscopy work, the Raman effect, as well as the advantages and disadvantages of Raman spectroscopy.
- Site Preparation Checklists
- User Manuals
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Videos
Read reviews on the TRS100 Raman pharmaceutical analysis system
Explore customer reviews posted on SelectScience, or write your own review.
TRS Return-on-Investment Value Calculator
See how much and how soon you could save compared to your current content uniformity workflow.
Molecular Spectroscopy Pharma & Biopharma Solutions Guide
Learn about products & applications in pharma & biopharma using UV-Vis, FTIR, fluorescence, SORS & TRS technology.
Raman Spectroscopy FAQ Guide
Learn about how Raman spectroscopy works, the Raman effect, the advantages and disadvantages of Raman, and more.
Raman Spectroscopy Applications Guide
A guide to Raman spectroscopy applications using Agilent handheld and benchtop Raman analyzers.
AstraZeneca Webinar Discusses Extended Uniformity of Dosage Unit Testing of Pharmaceutical Tablets Using TRS
Transmission Raman spectroscopy (TRS) is non-destructive and high throughput, so can be applied to extended uniformity of dosage unit testing and enhanced control strategies aiming at real-time release for batch and continuous operations. Hear Anders Sparén, Associate Principal Scientist at AstraZeneca, present his team’s work showing why TRS is an ideal technique for the assessment of assay, uniformity of dosage unit, and polymorphs in tablets and capsules.
- 20 Mar 2023
Teva Uses the Agilent TRS100 to Achieve Regulatory Milestone for Content Uniformity Testing with the FDA
The FDA has approved a content uniformity (CU) method using the Agilent TRS100 Raman quantitative pharmaceutical analysis system. The submitting company, Teva Pharmaceutical Industries Ltd., is an Agilent Raman spectroscopy customer and global leader in generics and biopharmaceuticals. In 2021, the U.S. Food and Drug Administration (FDA) approved the company’s CU method application, which was developed using the TRS100 system.
- 05 Jul 2022
A Non-destructive Quantitative Transmission Raman Spectroscopy Method for API in Drug Product In-Use Samples Prepared in Dosing Vehicles
This new publication describes the TRS100 analyzing low levels (0.1-1% w/w) of active pharmaceutical ingredient in pediatric formulations of yogurt and apple sauce. This novel application analyzed samples in plastic bags using the TRS100 powder bag tray. They quoted ‘This work demonstrates the TRS can be used as a viable, accurate, cost effective and efficient method for API quantification in in-use samples prepared in dosing vehicles.’
- 25 May 2022
Jerry Jin
PAT Scientist at Allergan
The analysis of 10 pharmaceutical tablets for their content uniformity takes only several minutes, as compared to one day turnaround time when using a traditional HPLC method. Method development using TRS100 for material identification and quantitative assay is generally easier than other vibrational spectroscopic techniques such as near infrared (NIR). One intrinsic advantage of TRS is its excellent specificity. Considering the unique strength of Agilent’s TRS100 in pharmaceutical analysis, I expect to see its deployment in more QC labs for product identification and assay, as well as its deployment on factory floors for real-time release testing.
View MoreImplementing Transmission Raman for Fast Content Uniformity Testing – from Feasibility Evaluation to a Validated Release Method
The webinar highlights the approach that led to the implementation of transmission Raman spectroscopy for content uniformity testing at a pharmaceutical company. The webinar also discusses the reasons for using transmission Raman spectroscopy for content uniformity and how it works in conjunction with established liquid chromatography (LC) methods.
Solid State Analysis in Pharmaceutical Formulation Development: Advantages and Limitations of Transmission Raman and LDIR Chemical Imaging techniques
Transmission Raman Spectroscopy (TRS) is licensed in the pharmaceutical industry for the identification and determination of bulk assay and uniformity of content of finished products. The first part of this webcast will cover the basic principles of Raman spectroscopy, discussing the advantages and limitations over conventional testing methods, the process and steps required to select suitable products for Raman testing, and the development and validation requirements of Raman methods and models. This presentation will also review regulatory submissions of Raman methods and the lifecycle maintenance of licensed Raman models. The second part of this webcast will describe how LDIR technology can enable rapid, high-quality surface imaging of large tablet surfaces, for applications including polymorph screening in the formulation.
Pharmaceutical Formulation Development
This webcast describes the use of molecular spectroscopy techniques—Transmission Raman Spectroscopy (TRS) and Laser Direct Infrared (LDIR)—for solid-state analysis in pharmaceutical formulation development. In the first of two presentations, Ashish Punia from Merck & Co. will discuss “Drug Product Identification and Physical Stability Analysis by Transmission Raman based Chemometrics,” describing the significant application of transmission Raman spectroscopy in pharmaceutical drug identification and stability analysis. Darren Robey of Agilent Technologies will then present “Advances in Chemical Imaging for Pharmaceutical Formulation Development using Laser Based Infrared Spectroscopy,” focusing on fast chemical imaging of tablet surfaces by LDIR.
- Publications
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- A non-destructive quantitative transmission Raman spectroscopy method for API in drug product in-use samples prepared in dosing vehicles, G. Doddridge, E. Hong, D.C.T. Tan et al., AAPS PharmSciTech 23, 132 (2022) Learn More
- Transmission Raman spectroscopy – Implementation in pharmaceutical quality control, Meike Römer; in 'Solid State Development and Processing of Pharmaceutical Molecules: Salts, Cocrystals, and Polymorphism', 79 (2021) 165-184 Learn More
- Analytical method development using transmission Raman spectroscopy for pharmaceutical assays and compliance with regulatory guidelines—Part II: Practical Implementation Considerations, B. Igne et al., J. Pharm. Innov., 14 2019 Learn More
- Analytical method development using transmission Raman spectroscopy for pharmaceutical assays and compliance with regulatory guidelines—Part I: TRS and method development, D. Andrews et al., J. Pharm. Innov., 13 (2018) Learn More
- Calibration transfer between modelled and commercial pharmaceutical tablet for API quantification using backscattering NIR, Raman and transmission Raman spectroscopy (TRS), X. Wang et al., Journal of Pharmaceutical and Biomedical Analysis, 194 (2021) 113766 Learn More
- Manufacturing amorphous solid dispersions with a tailored amount of crystallized API for biopharmaceutical testing, F. Theil, H. van Lishaut et al., Abbvie Deutschland GmbH & Co., Molecular Pharmaceutics, 15 (2018) Learn More
- Quantifying low levels (<0.5% w/w) of warfarin sodium salts in oral solid dose forms using Transmission Raman spectroscopy, J. Griffen, A. Owen and P. Matousek, Journal of Pharmaceutical and Biomedical Analysis, 155 (2018) Learn More
- Rapid quantitation of atorvastatin in process pharmaceutical powder sample using Raman spectroscopy, Y. Lim, M. J. Kang et al., Chong Kun Dang Pharm. and Dankook University, Spectrochim. Acta Part A: Mol. and Biomol. Spectr., 200 Learn More
- View all spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) peer-reviewed publications Learn More
Transmission Raman Spectroscopy (TRS)
Transmission Raman Spectroscopy (TRS) is an ideal method for quantitative analysis of mixtures such as tablets capsules, powders, liquids and suspensions.
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