The TRS100 quantitative pharmaceutical analysis system
TRS100 Quantitative Pharmaceutical Analysis System
The TRS100 enables fast, easy-to-use whole tablet or capsule content uniformity and polymorph screening for pharmaceutical finished-product testing and formulation development. Easier to implement than other spectroscopic methods, Agilent's transmission Raman spectroscopy (TRS) technology allows simple method development and deployment for quantitative analysis in quality control applications.
A TRS100 system can reduce content uniformity, assay, and ID tests to minutes per batch, saving significant cost and speeding up your quality control workflow. Sample preparation and consumables are not needed, meaning skilled analytical resources are not required. Content uniformity testing methods using transmission Raman have been approved by regulators using ICH and regulatory authority-acceptable protocols.
A TRS100 system can reduce content uniformity, assay, and ID tests to minutes per batch, saving significant cost and speeding up your quality control workflow. Sample preparation and consumables are not needed, meaning skilled analytical resources are not required. Content uniformity testing methods using transmission Raman have been approved by regulators using ICH and regulatory authority-acceptable protocols.
Product Details
Features
- Assay hundreds of tablets or capsules in minutes
- Works with intact capsules and coated tablets of most thicknesses
- No sample preparation, wet chemistry, or skilled testing resources needed
- Quantifies APIs and excipients in a single measurement
- Limit of quantification as low as 0.1% w/w
- Quantifies polymorphs in intact tablets
- Lean calibration models—easy to build and maintain
- Methods approved by regulators
- A range of sample trays and accessories for tablets, capsules, liquids, and powders are available
- Built-in technical controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11 and EU Annex 11 regulations
How It Works
Applications
Featured References
- Publications
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- A Non-destructive Quantitative Transmission Raman Spectroscopy Method for Active Pharmaceutical Ingredient in Drug Product In-Use Samples Prepared in Dosing Vehicles, G. Doddridge, E. Hong, D.C.T. Tan et al., AAPS PharmSciTech 23, 132 (2022) Learn More
- Transmission Raman spectroscopy–Implementation in Pharmaceutical Quality Control, Meike Römer, Solid State Development and Processing of Pharmaceutical Molecules: Salts, Cocrystals, and Polymorphism, 79 (2021) 165-184 Learn More
- Analytical method development using transmission Raman spectroscopy for pharmaceutical assays and compliance with regulatory guidelines—Part II: Practical Implementation Considerations, B. Igne et al., J. Pharm. Innov., 14 2019 Learn More
- Analytical method development using transmission Raman spectroscopy for pharmaceutical assays and compliance with regulatory guidelines—Part I: TRS and method development, D. Andrews et al., J. Pharm. Innov., 13 (2018) Learn More
- Calibration transfer between modelled and commercial pharmaceutical tablet for API quantification using backscattering NIR, Raman and transmission Raman spectroscopy (TRS), X. Wang et al., Journal of Pharmaceutical and Biomedical Analysis, 194 (2021) 113766 Learn More
- Manufacturing amorphous solid dispersions with a tailored amount of crystallized API for biopharmaceutical testing, F. Theil, H. van Lishaut et al., Abbvie Deutschland GmbH & Co., Molecular Pharmaceutics, 15 (2018) Learn More
- Quantifying low levels (<0.5% w/w) of warfarin sodium salts in oral solid dose forms using Transmission Raman spectroscopy, J. Griffen, A. Owen and P. Matousek, Journal of Pharmaceutical and Biomedical Analysis, 155 (2018) Learn More
- Rapid quantitation of atorvastatin in process pharmaceutical powder sample using Raman spectroscopy, Y. Lim, M. J. Kang et al., Chong Kun Dang Pharm. and Dankook University, Spectrochim. Acta Part A: Mol. and Biomol. Spectr., 200 Learn More
- View all spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) peer-reviewed publications Learn More