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Raman Spectroscopy

Innovative Raman Technology for Noninvasive Through-Barrier Chemical Analysis

Agilent Raman spectroscopy systems use proprietary spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) in fields ranging from airport security screening and pharmaceutical quality control, to hazardous chemical identification in the field.

SORS enables chemical analysis through containers and opaque barriers, from helping first responders identify the contents of suspect packages, to high-throughput raw material identification inside unopened packaging at pharmaceutical quality control. TRS nondestructively screens whole tablets and capsules in seconds, for rapid content uniformity and polymorph analysis in pharma QC and formulation development.

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Featured Literature

Agilent Resolve Handheld Raman Analyzer for Through-Barrier Chemical Identification

Agilent Resolve is the world’s only handheld Raman system that enables true through-barrier identification of hazardous or contraband materials.

Agilent Raman Solutions for Pharmaceutical QC

Lower your costs and streamline your workflows in raw material identification, content uniformity testing, and polymorph analysis in pharmaceutical QC

Solutions for Accelerated Raw Materials Identification

This e-book describes how a through-container handheld Raman instrument can be used to reduce the turn around time and cost of pharmaceutical raw material quality control

Verifying Raw Materials by Spatially Offset Raman Spectroscopy

The Agilent Vaya and RapID instruments use Spatially Offset Raman Spectroscopy (SORS) for identifying materials inside unopened packaging

Featured Videos
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Featured News

SPIE Paper Discusses Detection and Identification of Hazardous Narcotics and New Psychoactive Substances (NPS) Using Resolve Raman

This study describes the use of Raman SORS technology for rapid identification of narcotics in a range of concentrations – from pure form (as it is smuggled or transported) to street forms and products, often mixed with conventional cutting agents. The paper discusses the potential to improve safety, efficiency and critical decision making in incident management, search operations, policing and ports and border operations.

Application Note Describes Quantification and Identity Testing of Soft Gel Capsules using Transmission Raman Spectroscopy

This application note discusses how the TRS100 can be used to generate both a qualitative (ID) and quantitative analysis of soft gel capsules. The processes of calibration, model development, and method validation are also discussed. This study presents an efficient and cost saving analytical technique requiring no sample preparation.

RapID Used in the Analysis of Alcohol-Based Hand Sanitizers

The Covid-19 pandemic has increased the need for disinfectants and in particular alcohol hand sanitizers. An article by the FDA St. Louis OTR team, published in Nature, describes how the quality of these hand sanitizers can be assessed without sampling. Active ingredients (e.g., alcohol) of commercial sanitizers were identified and quantified, regardless of the container material or opacity, using spatially offset Raman spectroscopy. The FDA team used the Agilent RapID to acquire the Raman signal of the hand sanitizer directly through transparent and opaque plastic containers. (RA44459.4152314815)

Featured Training & Events

Through Container Verification of Pharmaceutical Raw Materials with the New Agilent Vaya Handheld Raman System

This webcast describes raw material verification testing through transparent and non-transparent packaging using the new Agilent Vaya Raman system. Vaya is the first handheld Raman spectrometer incorporating spatially offset Raman spectroscopy (SORS) technology for the quick identification of raw materials through containers. SORS reduces the need for sampling, saving cost, and resources by testing incoming goods quickly in the warehouse. Vaya combines the capabilities of conventional Raman systems with SORS for maximum sample/container compatibility. A range of container/material combinations will be discussed.

Implementing Transmission Raman for Fast Content Uniformity Testing – from Feasibility Evaluation to a Validated Release Method

The webinar highlights the approach that led to the implementation of transmission Raman spectroscopy for content uniformity testing at a pharmaceutical company. The webinar also discusses the reasons for using transmission Raman spectroscopy for content uniformity and how it works in conjunction with established liquid chromatography (LC) methods.

Molecular Spectroscopy Webinar Curriculum

Molecular Spectroscopy Webinar Curriculum includes UV-Vis, UV-Vis-NIR, fluorescence, handheld and benchtop FTIR, and Raman systems for high performance and flexibility

Workflow Breakthroughs - Improving Data Quality and Efficiency and Changing Pharmaceutical Analysis

Learn about new technologies that can dramatically reduce the risks around routine pharmaceutical analysis while also reducing the time required from hours and days to minutes.
Featured References
  1. View all spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) peer-reviewed publications Learn More

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