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Raman Spectroscopy

Innovative Raman Spectrometers for Noninvasive Chemical Analysis

Agilent Raman spectrometers use proprietary spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) in fields ranging from airport security screening and pharmaceutical quality control, to hazardous chemical identification in the field.

SORS enables our Raman spectrometers to analyze through containers and opaque barriers, from helping first responders identify the contents of suspect packages, to high-throughput raw material identification inside unopened packaging at pharmaceutical quality control. TRS nondestructively screens whole tablets and capsules in seconds, for rapid content uniformity and polymorph analysis in pharma QC and formulation development.
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Featured Literature

Identification of Oligonucleotide Starting Materials Directly Through Containers

Use of the Agilent Vaya Raman handheld spectrometer for the identification of oligonucleotide starting materials, phosphoramidites, directly through amber bottles.

  • Application Notes
  • 770.37 KB

Quantification and Identity Testing of Soft Gel Capsules using Transmission Raman Spectroscopy

This study presents an efficient and cost saving analytical technique requiring no sample preparation

  • Application Notes
  • 638.73 KB

Solutions for Accelerated Raw Materials Identification

This e-book describes how a through-container handheld Raman instrument can be used to reduce the turn around time and cost of pharmaceutical raw material quality control

  • Primers
  • 3.11 MB

Detection of Hazardous Narcotics and New Psychoactive Substances (NPS) with Agilent Resolve—a Handheld SORS System

Use of Resolve allows the examination a maximum range of packages or containers for indications of hazardous materials before disturbing, opening, or taking a sample.

  • Application Notes
  • 1.67 MB
Featured Videos

Clandestine Lab Search with Resolve Raman

  • 00:01:32

Increase Your Reach, Not Your Costs with the Agilent Vaya Handheld Raman Spectrometer

  • 00:02:08

Smarter Pharmaceutical Analysis with TRS100

  • 2:09

Bottle Scanner for Liquids, Aerosols and Gels using Insight200M

  • 00:02:28
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Featured News

A Non-destructive Quantitative Transmission Raman Spectroscopy Method for API in Drug Product In-Use Samples Prepared in Dosing Vehicles

This new publication describes the TRS100 analyzing low levels (0.1-1% w/w) of active pharmaceutical ingredient in pediatric formulations of yogurt and apple sauce. This novel application analyzed samples in plastic bags using the TRS100 powder bag tray. They quoted ‘This work demonstrates the TRS can be used as a viable, accurate, cost effective and efficient method for API quantification in in-use samples prepared in dosing vehicles.’

  • 25 May 2022

SelectScience Webinar: Transmission Raman - A Versatile Tool for Pharmaceutical Formulation Development to End-Product Testing

In this webinar, join Dr. Frank Theil, head of physical analytical chemistry, and Greg Doddridge, principal research scientist at AbbVie, as they explore and demonstrate the key pharmaceutical applications of transmission Raman spectroscopy (TRS).

  • 03 May 2022

Application Note Describes Handheld Raman ID of Oligonucleotide Starting Materials Directly Through Containers

Handheld Raman spectrometers can selectively identify oligonucleotide starting materials, also known as phosphoramidites, directly through amber bottles. This application note discusses the theory and deployment of Agilent handheld Raman systems for identity verification of phosphoramidites in a GMP environment.

  • 15 Dec 2021
Featured Training & Events

Through Container Verification of Pharmaceutical Raw Materials with the New Agilent Vaya Handheld Raman System

This webcast describes raw material verification testing through transparent and non-transparent packaging using the new Agilent Vaya Raman system. Vaya is the first handheld Raman spectrometer incorporating spatially offset Raman spectroscopy (SORS) technology for the quick identification of raw materials through containers. SORS reduces the need for sampling, saving cost, and resources by testing incoming goods quickly in the warehouse. Vaya combines the capabilities of conventional Raman systems with SORS for maximum sample/container compatibility. A range of container/material combinations will be discussed.
Webinar/Training

Implementing Transmission Raman for Fast Content Uniformity Testing – from Feasibility Evaluation to a Validated Release Method

The webinar highlights the approach that led to the implementation of transmission Raman spectroscopy for content uniformity testing at a pharmaceutical company. The webinar also discusses the reasons for using transmission Raman spectroscopy for content uniformity and how it works in conjunction with established liquid chromatography (LC) methods.
Webinar/Training

Molecular Spectroscopy Webinar Curriculum

Molecular Spectroscopy Webinar Curriculum includes UV-Vis, UV-Vis-NIR, fluorescence, handheld and benchtop FTIR, and Raman systems for high performance and flexibility
Webinar/Training

Workflow Breakthroughs - Improving Data Quality and Efficiency and Changing Pharmaceutical Analysis

Learn about new technologies that can dramatically reduce the risks around routine pharmaceutical analysis while also reducing the time required from hours and days to minutes.
Webinar/Training
Featured References
  1. View all spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) peer-reviewed publications Learn More

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