
6495C Triple Quadrupole LC/MS
Featuring third-generation iFunnel design and VacShield for easy maintenance, the 6495C represents an unrivaled combination of high performance and high reliability.
- Triple Quadrupole LC/MS
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Product Details
- Most sensitive Agilent LC/TQ delivers confidence into the ppt range and beyond
- Reliability to match performance with a 3rd-generation all-metal iFunnel design
- Wide mass range of m/z 5-3,000 gives you the flexibility to handle any MRM transition
- Vent-free ion source maintenance with VacShield technology
- Screen, confirm, and quantify with triggered MRM (tMRM), which acts like normal MRM until it sees your compound, then instantly expands to generate a product ion spectrum perfect for a library search to confirm
- Direct Skyline integration to streamline peptide quantitation method development and analysis
- Built-in technical controls combined with procedural controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11, EU Annex 11 and similar national electronic record regulations
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- Key Literature
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A Comprehensive, Curated, High-Throughput Method for the Detailed Analysis of the Plasma Lipidome
In this application note, we describe an LC/MS/MS-based method for the determination of 761 different human lipid species using a 10 µL volume of plasma.
- Application Notes
- English
- 13 Oct 2021
- 3.74 MB
Absolute Quantitation of Fragile Metabolites by Isotope Dilution Mass Spectrometry on the Agilent 6495 Triple Quadrupole LC/MS
The Agilent 6495 LC/TQ with iFunnel preserved fragile analytes and improved sensitivity allowing absolute quantiation of metabolites using IDMS.
- Application Notes
- English
- 22 Feb 2022
- 2.12 MB
Peptide Quantification in Plasma Using the Agilent 6495 Triple Quadrupole LC/MS Coupled with the Agilent 1290 Infinity II LC System
This application note showcases the quantitative performance of multiple reaction monitoring (MRM)-based LC/MS analysis of peptides derived from protein biomarkers in human plasma using the Agilent 1290 Infinity II LC system coupled to the Agilent 6495 triple quadrupole LC/MS with Jet Stream ionization source.
- Application Notes
- English
- 11 Sep 2020
- 545.44 KB
- Application Notes
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- FAQs
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Instrument Detection Limit Frequently Asked Questions (FAQ)
An Introduction to Using Instrument Detection Limit as a Performance Metric
- Quick Reference Guides
- Site Preparation Checklists
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6495C Method Development Best Practices
Learn how to get the highest performance from your Agilent 6495C triple quadrupole LC/MS
Dr. rer. Nat Tobias Minuth
Lower Saxony State Agency for Water Management, Coastal Defence and Nature Conservation - NLWKN - Hannover - Hildesheim, Dept. for Organic Trace Analysis
The PFAS measurement method was very time-saving and easy to establish, so that our routine procedures and the productivity of the laboratory could continue as usual and without disruptions. We were able to start routine measurement of more than 50 PFAS compounds in a very short time using the Agilent PFAS MRM database on our Agilent 1290 Infinity II/6495-QQQ system. The PFC-free HPLC elimination kit was easy to install and allowed us to significantly reduce PFAS blank values. Thanks to the collaboration with Agilent, we were able to provide our customers with a very reliable and highly accurate analysis of PFAS analytes in a very short time.
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Poly- and Perfluoroalkyl Substances in Water: Challenges and mitigating strategies in Detection and Treatment
In this webinar you will learn how to overcome challenges in analysis of PFAS and mitigation using existing and novel water treatment technologies for the removal of PFAS.
Agilent Education Online Education Learning Path for 6400 Series QQQ LC/MS
A learning path is available from Agilent Education.