6230 LC/TOF with the 1290 Infinity II Bio LC System
6230B Time of Flight (TOF) LC/MS
The 6230B TOF LC/MS is fully compatible with Agilent Bio-inert HPLC systems making it an ideal tool for intact protein characterization, glycan, and oligonucleotide analysis. The high resolution and accurate mass enable detection and identification of Extractables and Leachables (E&L), and many other impurities and target compounds. Advanced and intuitive software tools like one-click SWARM autotune and WalkUp software allow anyone to routinely achieve reliable results. The 6230B TOF LC/MS MassHunter software suite is compliance ready.
- Time of Flight LC/MS
Request a Quote
Product Details
- Reduce false positives with better than 1 ppm mass accuracy
- Ensure excellent data quality even for fast UHPLC peaks in high-throughput workflows with data acquisition rates up to 44 spectra/second
- Identify compounds based on accurate mass, isotopic abundance, and chemical composition using Find by Formula in MassHunter software
- Analyze monoclonal antibodies (mAb) with high mass accuracy and resolving power for glycoforms and truncation
- Characterize large biologic compounds with a broad mass range of up to 20,000 m/z
- Separate target compounds from interferences with high-resolution data
- Find impurities at extremely low concentrations, using Agilent Jet Stream technology with low picogram on-column sensitivity
- Identify trace-level target compounds in the presence of more abundant matrix compounds with up to five orders of in-spectrum dynamic range
- Reduce administrative tasks and risks while eliminating the need for LC/MS expertise with intuitive MassHunter Walkup software
- Perform untargeted screening with optional fragmentation data using in-source dissociation
- Reduce administrative tasks and risks while eliminating the need for LC/MS expertise with intuitive MassHunter WalkUp software
- Go beyond UHPLC separation with support for capillary electrophoresis, SFC, 2D-LC, and even GC-APCI chromatographic interfaces.
| In-spectra Dynamic Range |
|
| Ion Source |
|
| MS Acquisition Rate |
|
| MS Mass Accuracy (positive) |
|
| Polarity Switching Duty Cycle |
|
| Software Platform |
|
| Supported Software Add-Ons |
|
| TOF Mass Range |
|
| TOF Mass Resolution (FWHM) |
|
| Temperature Mass Stability |
|
Additional Technology and Software Capabilities for LC/Q-TOF
Agilent partners with selected companies who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF!
Learn More- Key Literature
-
Analysis of Monoclonal Antibodies
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
- Application Notes
- English
- 03 Feb 2016
- 778.87 KB
Metabolomics Batch Data Analysis Workflow to Characterize Differential Metabolites in Bacteria
"This discovery metabolomics application uses Q-TOF LC/MS to identify and understand the biological and biochemical nature of bacterium.
- Application Notes
- English
- 28 Apr 2015
- 3.21 MB
Rapid and Accurate Forensics Analysis using High Resolution “All Ions MS/MS”
This application note describes the use of a new technique, “All Ions MS/MS”, to rapidly screen and identify drugs of forensic toxicological interest.
- Application Notes
- English
- 01 Mar 2018
- 2.11 MB
- Application Notes
- Brochures
- Flyers
- Posters
- Technical Overviews
- White Papers
- Support
-
MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use your MassHunter Data Acquisition for Agilent LC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: • Workstation (standalone, no content management) • Networked Workstation (networked, with content management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
MassHunter Networked Workstation Functional Design Specifications
This document contains the Functional Design Specifications for your Agilent MassHunter Networked Workstation system.
- Specifications
- English
- 17 Nov 2022
- 13.06 MB
- FAQs
- Quick Reference Guides
- Site Preparation Checklists
- Supplemental Information
- User Manuals
Didn't find what you need? Contact our support team.
Videos
Agilent University
Develop skills and improve lab productivity with a wide variety of learning options from Agilent Education.
Peptide Mapping Using LC/MS
A step-by-step workflow review of peptide mapping using LC/MS
Emerging Omics Webinar Series
This ongoing webinar series will cover topics of interest to researchers using genomics, transcriptomics, proteomics, and metabolomics.
Agilent Announces Inspirational LC/TQ and LC/Q-TOF Mass Spectrometry Solutions at ASMS 2023
Agilent Technologies announced two new liquid chromatography mass spectrometry systems (LCMS), the Agilent 6495D LC/TQ and the Agilent Revident LC/Q-TOF. Facilitating the high-end performance of the Revident LC/Q-TOF, Agilent is also announcing the new Agilent MassHunter Explorer Profiling software and the new Agilent ChemVista library manager software.
- 05 Jun 2023
Agilent Announces New Oligonucleotide Analysis Software for Biopharma Research
Agilent MassHunter BioConfirm 12.0 software introduces enhancements to existing capabilities for protein analysis and adds support for ligonucleotide analysis. The addition of oligonucleotide support significantly extends the capabilities of MassHunter BioConfirm, adding critical functionality for assessing oligonucleotide purity and sequence confirmation – important analytical steps in the use of oligonucleotides for biotherapeutics and vaccine research and development.
- 05 Jun 2022