6546 LC/Q-TOF
With Q-RAI (Quadrupole Resolved All Ions) or All Ions acquisition, food safety screening can now be combined with fragment information for identification, allowing you to conduct target and suspect screening simultaneously. In addition, for metabolomics research, the resolution increase together with broad dynamic range and isotopic fidelity makes the 6546 LC/Q-TOF the ideal platform.
- Quadrupole Time of Flight LC/MS
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Product Details
- Gain confidence at the low and high concentrations with simultaneous delivery of five orders of in-spectrum dynamic range and mass resolution over 60k (for high masses) and over 30k (for low masses)
- Narrow down identification possibilities through sub-ppm mass accuracy and isotope fidelity within 5%
- Experience easy maintenance with vent-free access to ion source and inlet
- Move beyond analytical targeted screening restriction on number of compounds and time-consuming method maintenance with accurate mass spectral libraries for pesticides, veterinary drugs, mycotoxins, extractables and leachables, and water contaminants
- Access metabolomics workflows for profiling, lipidomics, and qualitative flux analysis
- Use the new food authenticity workflow to streamline analysis when testing for product origin or adulteration
- Key Literature
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Extracellular Flux Analysis and 13C Stable-Isotope Tracing Reveals Metabolic Changes
Combining real-time extracellular flux information with 13C stable‑isotope‑tracing allows greater insight into the mechanism of macrophage activation.
- Application Notes
- English
- 16 Apr 2020
- 733.53 KB
Lipid Profiling Workflow Demonstrates Disrupted Lipogenesis Induced with Drug Treatment in Leukemia Cells
The Agilent lipidomics profiling workflow, using the Agilent 6546 LC/Q-TOF and Agilent MassHunter Lipid Annotator software, was applied to the study of drug treated acute myeloid leukemia (AML) cells, revealing lipid differences through expanded coverage
- Application Notes
- English
- 17 Sep 2020
- 2.26 MB
Drug Screening in Whole Blood Using the Agilent 6546 LC/Q-TOF and the LC Screener Tool with Automated Sample Preparation
This application note describes a method for the routine screening of drugs and their related metabolites in whole blood, using the 6546 LC/Q-TOF and Bravo automated linquid handling platform.
- Application Notes
- English
- 18 Mar 2022
- 2.16 MB
- Application Notes
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- Site Preparation Checklists
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LC/MS Site Preparation Guide
Interactive Site Prep Guide for all LC/MS instruments. Download, unzip, and run index.htm.
- Site Preparation Checklists
- English
- 11 Dec 2021
- 536.26 MB
- ZIP
Nicola Zamboni, PhD
ETH Zurich, Switzerland
"The 6546 is a major advancement compared to previous TOFs, mainly because it combines dynamic range with excellent resolution in all conditions (speed, mass range, intensity). In our hands, the 6546 is going to be a great instrument for challenging applications such as 13C metabolic flux analysis, high-throughput mass spectrometry, and metabolite ID."
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