Villin is a 95 kDa calcium-regulated, actin-binding protein that plays a role iin regulating actin filament assembly. It is a major constituent in the microvilli, which compose the brush border of epithelial cells forming absorptive surfaces of the intestinal and renal proximal tubular epithelia. In normal human tissue, villin is expressed by a limited number of simple epithelia of the gastrointestinal and urogenital tract. Antibodies to villin are a useful aid for classification of primary and metastatic colorectal carcinomas.
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Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Purified porcine villin (9). See package insert for reference(s).
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Autostainer Link 48
Anti-Villin, clone 1D2 C3 recognizes a well-conserved epitope found in the head piece of villin and reacts with human, chicken, pig, rat, and Xenopus laevis villin-equivalent protein in immunoblotting (9).In Westernblotting of HeLa cells transfected with cDNAs encoding wild type human villin or villin variants the antibody labels a band of approximately 95 kDa corresponding to the expected molecular weight of villin (10). See package insert for reference(s).