Tyrosinase is a copper-glycoenzyme involved in the production of melanin pigments, including both eumelanin and pheomelanin. As a marker of melanocytic lineage, tyrosinase is localized to melanocytes which can be found on the dermal/epidermal junction of normal skin. It is not detected in other normal cells. Results aid in the classification of primary and metastatic malignant melanomas. The cellular localization of tyrosinase is cytoplasmic and/or perinuclear.