Synaptophysin is a 38 kDa membrane glycoprotein expressed in neuroendocrine cells and neurons involved in transmission via synaptic vehicles.
Results aid in the classification of neuroendocrine neoplasms, such as neuroendocrine lung tumors (e.g. carcinoid, atypic carcinoid, SCLC, LCNEC and non-small cell lung cancer), neuroendocrine tumors of the gastroenteropancreatic tract, e.g. neuroendocrine tumors (NETs), neuroendocrine carcinoma (NECs) and other epithelial neuroendocrine neoplasms such as pituitary adenomas, medullary thyroid carcinoma and parathyroid adenomas.
Clone DAK-SYNAP is raised against a recombinant immunogen corresponding to the C-terminal cytoplasmic domain of human synaptophysin.