Prostatic intraepithelial neoplasia (PIN)

Prostate-Specific Membrane Antigen (Autostainer Link 48)

Clone 3E6

Prostate-specific membrane antigen (PSMA) is expressed in normal and malignant prostatic epithelium and in a subset of non-prostatic tissues. In prostate cancer, PSMA expression has been shown to correlate with disease progression, with highest levels expressed in hormone-refractory and metastatic disease. The cellular localization of PSMA is cytoplasmic and/or membranous.

This antibody labels PSMA-expressing cells in normal and neoplastic tissues and is a useful aid for classification of prostate adenocarcinomas.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	3E6
Code Number	IR089
Immunogen	LNCaP membrane preparation and immunoaffinity purified PSMA (3). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	Monoclonal mouse anti-PSMA has been demonstrated to react in Western blotting with PSMA from LNCaP cell lysate, seminal fluid and with recombinant baculovirus expressed PSMA. Clone 3E6 also binds a 100 kD protein in LNCap lysates, corresponding to PSM. Monoclonal anti-PSMA clone 3E6 recognizes an epitope present in the 57-134 amino acid region of the extracellular portion of the PSMA molecule, as determined by Western blot analysis of baculovirus expressed PSMA fragments (3). See package insert for reference(s).

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Featured References

Product Description References: 1. Mannweiler S, Amersdorfer P, Trajanoski S, Terrett J, King D, Mehes G. Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol Oncol Res 2009,15:167-72.

Prostate-Specific Membrane Antigen (Autostainer Link 48)

Product Details

Atlas of Controls

View supported Instructions For Use documents

1. Mannweiler S, Amersdorfer P, Trajanoski S, Terrett J, King D, Mehes G. Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol Oncol Res 2009,15:167-72.

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