This monoclonal mouse antibody reacts with human progesterone receptor (PR), a steroid hormone receptor that plays an important role in breast cancer. Historical studies have shown that estrogen receptor (ER) and PR status is correlated with untreated outcome (i.e. prognostic for well-differentiated invasive breast cancer) and with response to anti-hormonal therapy (1). Generally, the absence of ER and PR may indicate early recurrence and poor survival of breast cancer patients, while the presence of ER and PR in breast tumors may indicate potential benefit from tamoxifen and other anti-hormonal therapies. The antibody may be used in the semi-quantitative detection of human progesterone receptor in tissue sections of human breast cancer by immunohistochemistry.
This product is not available for purchase by the general public.
Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
HIER
Clone
PgR 1294
Code Number
M3568
Immunogen
Formalin-fixed recombinant full-length A-form of human progesterone receptor (1). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Anti-PR, PgR 1294 is available as a mouse anti-human monoclonal antibody tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2, containing 0.015 mol/L NaN3 and stabilizing protein.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
Anti-PR, PgR 1294 has been demonstrated to react with the PR-A and PR-B forms by Western blot of whole cell extracts and reacts with both free and hormone-bound PR (1). The epitope has been mapped to the amino terminal domain shared by PR-A and PR-B. See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.