Postmeiotic Segregation Increased 2 (Autostainer Link 48)
Clone EP51
Postmeiotic segregation increased 2 (PMS2) is part of the DNA mismatch repair (MMR) pathway, which is utilized by normal proliferating cells to repair mutations that may occur during DNA replication.
Antibodies to PMS2 may be a useful aid for classification of tumors of the gastrointestinal tract, including HNPCC and associated extracolonic cancers.
This product is not available for purchase by the general public.
Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
EP51
Code Number
IR087
Immunogen
Synthetic peptide corresponding to residues in human PMS2 protein.
Isotype
Rabbit IgG
Reagent Provided
Ready-to-use monoclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Autostainer Link 48
Species
Anti-Human
Specificity
In Western blotting of SHSY5Y cells, anti-PMS2, clone EP51, recognizes a major band at 110 kDa corresponding to the expected molecular weight of PMS2.
1. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9. 2. Lynch H. Smyrk, T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated Review. Cancer 1996,78:1149-67.