p63 protein is a member of the p53 tumor suppressor family which also includes the p73 protein. These proteins act as transcription factors that regulate the progression of the cell through its cell cycle and cell death (apoptosis) in response to environmental stimuli, such as DNA damage and hypoxia. The p63 protein is expressed in the nucleus of basal cells in many types of epithelium.
The predominant localization of p63 protein is in basal cells of normal epithelia in ectocervix, esophagus, prostate, skin, tonsil, urothelium and vagina, and in basal cells in glandular structures of breast, bronchi and prostate. p63 protein is also expressed in myoepithelial cells of the breast. Antibodies to p63 protein may be useful as an aid in the classification of benign prostate lesions and prostate adenocarcinoma, breast carcinoma in situ and breast carcinoma, squamous cell carcinoma and adenocarcinoma of the lung and furthermore to classify uterine cervical squamous carcinoma and cervical adenocarcinoma.
The new clone DAK-p63 is raised against a synthetic peptide derived from the core DNA-binding domain of human p63 protein thus reacting with TAp63 and ΔNp63 isoforms of p63.