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p40 (Dako Omnis)

Clone DAK-p40

The p63 protein exist in two isoforms TAp63 and ΔNp63. The ΔNp63 isoform is also denoted p40. Antibodies against p63 detect both isoforms whereas p40 antibodies only detect the ΔNp63 isoform.

The p63 protein is regulating cellular growth and its expression is correlated to cellular differentiation. Detection of p40 expression by immunohistochemistry is used as an aid in classification of lung squamous cell carcinoma.

Primary Antibodies

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis

Specifications


Application	Formalin HIER
Clone	DAK-p40
Code Number	GA784
Immunogen	Synthetic peptide within N-terminal of human p40 (ΔNp63).
Reagent Provided	Ready-to-use monoclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Dako Omnis
Specialty	Lung
Species	Rabbit Anti-Human
Specificity	In ELISA, reactivity of the p40 antibody (clone DAK-p40) has been shown against a p40-specific protein fragment. DAK-p40 labels ΔNp63α, ΔNp63β and ΔNp63γ isotypes.

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Featured References

Product Description References: 1. Sailer V, Stephan C, Wernert N, et al. Comparison of p40 (ΔNp63) and p63 expression in prostate tissues--which one is the superior diagnostic marker for basal cells? Histopathol 2013;63(1):50-6.
2. Bishop JA, Teruya-Feldstein J, Westra WH, et al. p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol 2012;25(3):405-15.

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p40 (Dako Omnis)

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