Tonsil

p16 (Dako Omnis)

Clone JC8

p16 inhibitor of CDK4, p16INK4a, is a 16 kDa tumor suppressor protein. It works as an inhibitor of the CDK4/CDK6-mediated cell cycle regulation of the G1/S phase transition. A decrease in p16 expression can lead to an upregulation of CDK4-mediated activation of retinoblastoma (Rb) protein accelerating cell proliferation. p16 expression has been observed in several cancers.

Primary Antibodies

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading international pathology experts.

Specifications


Application	HIER Formalin
Clone	JC8
Immunogen	Full length recombinant human p16
Isotype	IgG2a
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing BSA (bovine serum albumin) and 0.015 mol/L sodium azide. Amount in vial: 12 mL for 60 tests.
Species	Mouse Anti-Human
Specificity	In western blotting of HeLa cell lysate, the antibody labels a band at 16 kDa corresponding to the expected molecular weight of p16.

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Featured References

Product Description References: 1. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-7.

Featured

p16 (Dako Omnis)

Product Details

View supported Instructions For Use documents

1. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-7.

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