Nucleophosmin (Dako Omnis)
Reacts with nucleophosmin (NPM) and its mutated counterpart NPMc. NPM is predominantly localized in the nucleus of cells in most tissues. However, NPMc is aberrantly accumulated in the cytoplasm of leukemic blasts in a large subgroup of acute myeloid leukemia (AML) cases with a normal karyotype (1-2). The antibody may be a useful aid for classification of acute myeloid leukemia (3).
- Monoclonal Mouse Anti-Human
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Product Details
Features
- Optimized staining performance of both high and low-expression structures
- Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
- The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
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Literature
- Catalogs
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Atlas of Controls
The Atlas of Controls illustrates the staining performance of each antibody in the FLEX Ready-to-Use system.
- Catalogs
- English
- 26 Mar 2024
- 37.78 MB
- Technical Overviews
Support
- Instructions for Use
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Featured References
- Product Description References
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1. Falini B, Mecucci C, Tiacci E, Alcaly M, Rosatin R, Pasqualucci L, et al. Cytoplasmic nucleophosmin in acute myologenous leukemia with a normal karyotype. New Engl J Med 2005,352:254-66.
2. Falini B, Bolli N, Shan J, Martelli PM, Liso A, Pucciarini A, et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood 2006,107:4514-23.
3. Pasqualucci L, Liso A, Martelli MP, Bolli N, Pacini R, Tabarrinni A, et al. Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification. Blood 2006: Epub. ahead of print.
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