Myogenin belongs to a family of regulatory proteins essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin, and appears to be inversely related to the degree of cellular differentiation. The antibody recognizes an epitope located in the amino acid region 138-158 of the myogenin protein. The antibody is a useful aid for classification of rhabdomyosarcomas and Wilms' tumors. No reactivity with Ewing's sarcoma/peripheral primitive neuroectodermal tumor, neuroblastoma, or adult skeletal muscle has been observed. Myogenin peptide from rat has been used for immunization.
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Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Rat myogenin peptide (aa 73-94) conjugated to carrier protein and fusion peptide containing myogenin aa 30-224 (6). See package insert for reference(s).
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Autostainer Link 48
The antibody recognizes an epitope located in amino acid region 138–158 of the myogenin protein and has been found to label myogenin in human cultured myotubes (6). See package insert for reference(s).