MyoD1 (Concentrate)

Clone 5.8A

The MyoD1 protein is a 45 kDa nuclear phosphoprotein which induces myogenesis through transcriptional activation of muscle-specific genes. Nuclear expression of MyoD1 is restricted to skeletal muscle tissue and has been demonstrated to be a sensitive marker of myogenic differentiation. The antibody strongly labels the nuclei of myoblasts in developing skeletal muscle tissue, whereas the majority of adult skeletal muscle is negative. Results aid in the classification of rhabdomyosarcomas of various histological subtypes.

Monoclonal Mouse Anti-

Features

Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years’ experience ensuring quality and innovation in antibodies and reagents

Specifications


Application	Frozen Formalin HIER
Clone	5.8A
Code Number	M3512
Immunogen	Recombinant wild-type murine MyoD1 protein (1). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Monoclonal Mouse antibody provided in liquid form as tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2 and 0.015 mol/L sodium azide. This product contains stabilizing protein.
Solutions	Concentrate
Species	Mouse Anti-
Specificity	Monoclonal anti-MyoD1 has been shown by Western blot and immunoprecipitation assays to bind an epitope between amino acids 180-189 on the carboxy terminus of the MyoD1 protein (1). See package insert for reference(s).

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Featured References

Product Description References: 1. Dias P, Parham DM, Shapiro DN, Tapscott SJ, Houghton PJ. Monoclonal antibodies to the myogenic regulatory protein MyoD1: epitope mapping and diagnostic utility. Cancer Res 1992,52:6431-9.

MyoD1 (Concentrate)

Product Details

Immunohistochemical Staining Methods - Education Guide, Sixth Edition

View supported Instructions For Use documents

1. Dias P, Parham DM, Shapiro DN, Tapscott SJ, Houghton PJ. Monoclonal antibodies to the myogenic regulatory protein MyoD1: epitope mapping and diagnostic utility. Cancer Res 1992,52:6431-9.

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