The MyoD1 protein is a 45 kDa nuclear phosphoprotein which induces myogenesis through transcriptional activation of muscle-specific genes. Nuclear expression of MyoD1 is restricted to skeletal muscle tissue and has been demonstrated to be a sensitive marker of myogenic differentiation. The antibody strongly labels the nuclei of myoblasts in developing skeletal muscle tissue, whereas the majority of adult skeletal muscle is negative. Results aid in the classification of rhabdomyosarcomas of various histological subtypes.
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Recombinant wild-type murine MyoD1 protein (1). See package insert for reference(s).
Monoclonal Mouse antibody provided in liquid form as tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2 and 0.015 mol/L sodium azide. This product contains stabilizing protein.
Monoclonal anti-MyoD1 has been shown by Western blot and immunoprecipitation assays to bind an epitope between amino acids 180-189 on the carboxy terminus of the MyoD1 protein (1). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.