MutS protein homolog 6 (MSH6) is part of the mismatch repair (MMR) pathway which is utilized by normal proliferating cells to repair mutations that may occur during DNA replication. Antibodies to MSH6 are a useful aid for classification of tumors of the gastrointestinal tract, including associated extracolonic cancers.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
HIER
Clone
EP49
Code Number
M3646
Immunogen
Synthetic peptide corresponding to residues at the N-terminus of the human MSH6 protein.
Isotype
Rabbit IgG
Reagent Provided
Monoclonal rabbit antibody provided in liquid form as affinity-isolated antibody in a buffer containing 0.015 mol/L sodium azide. This product contains stabilizing protein.
Solutions
Concentrate
Species
Anti-Human
Specificity
In Western blotting of A431 cells lysates, anti-MSH6 clone EP49 recognizes a major band at 160 kDa corresponding to the expected molecular weight of MSH6.
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.
1. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9. 2. Lynch H. Smyrk, T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated Review. Cancer 1996,78:1149-67.