MutS protein homolog 6 (MSH6) is part of the mismatch repair (MMR) pathway which is utilized by normal proliferating cells to repair mutations that may occur during DNA replication. Antibodies to MSH6 are a useful aid for classification of tumors of the gastrointestinal tract, including associated extracolonic cancers.
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Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Synthetic peptide corresponding to residues at the N-terminus in human MSH6 protein.
Ready-to-use monoclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Autostainer Link 48
In Western blotting of A431 cells lysates, anti-MSH6 clone EP49 recognizes a major band at 160 kDa corresponding to the expected molecular weight of MSH6.
1. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9. 2. Lynch H. Smyrk, T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated Review. Cancer 1996,78:1149-67.