Appendix

MutS Protein Homolog 2 (Autostainer Link 48)

Clone FE11

MutS protein homolog 2 (MSH2) is part of the mismatch repair (MMR) pathway which is utilized by normal proliferating cells to repair mutations that may occur during DNA replication. Antibodies to MSH2 are a useful aid for classification of tumors of the gastrointestinal tract, including associated extracolonic cancers.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	FE11
Code Number	IR085
Immunogen	Recombinant protein comprising the carboxyl-terminal 330 amino acids of hMSH2 (15).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Anti-Human
Specificity	In Western blotting of human Sw480 and HCT116 colorectal cancer cell lysates, the antibody labels a major band at 97 kDa corresponding to the expected molecular weight of MSH2 (15). See package insert for reference(s).

Featured References

Product Description References: 1. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9.
2. Lynch H. Smyrk, T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated Review. Cancer 1996,78:1149-67.

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