Labels an intracytoplasmic antigen in the majority of melanocytes with immature melanosome formation in normal skin and nevus. The antibody also reacts with junctional and blue nevus cells. Results aid in the classification of melanomas and melanocytic lesions.
This product is not available for purchase by the general public.
Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Frozen
Formalin
Enzyme/HIER
Clone
HMB-45
Code Number
M0634
Immunogen
Extract of pigmented melanoma metastases from lymph nodes.
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2 and 0.015 mol/L sodium azide. This product contains stabilizing protein.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
Anti-Melanosome, HMB45 has been shown to react with a 10 kDa segment of a neuraminidase-sensitive sialylated glycoconjugate present in pre- and early-stage (immature) melanosomes (2-4). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.