Malignant melanoma

Melanosome (Autostainer Link 48)

Clone HMB-45

Labels an intracytoplasmic antigen in the majority of melanocytes with immature melanosome formation in normal skin and nevus. The antibody also reacts with junctional and blue nevus cells. Results aid in the classification of melanomas and melanocytic lesions.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	HMB-45
Code Number	IR052
Immunogen	Extract of pigmented melanoma metastases from lymph nodes.
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN₃.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	Anti-Melanosome, HMB45 has been shown to react with a 10 kDa segment of a neuraminidase-sensitive sialylated glycoconjugate present in pre- and early-stage (immature) melanosomes (2-4). See package insert for reference(s).

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