Mastocytosis in the bone marrow

Mast Cell Tryptase (Autostainer/Autostainer Plus)

Clone AA1

Human mast cell tryptases comprise a family of trypsin-like neutral serine proteases that are predominantly expressed in mast cells. These cells play an active role in such diverse diseases as atherosclerosis, asthma, arthritis, bile duct fibrosis, malignancy and pulmonary fibrosis. This antibody is a useful aid for classification of mast cell leukemia.

Monoclonal Mouse Anti-Human

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Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Clone	AA1
Immunogen	Mast cell tryptase isolated from human lung (3).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide. Clone: AA1 (3). Isotype: IgG1, kappa.
Solutions	Dako Autostainer/Autostainer Plus
Species	Mouse Anti-Human
Specificity	In Western blotting of a tryptase-rich extract of human lung under reducing conditions, the antibody labels a band of approximately 32.5 kDa corresponding to human mast cell tryptase (3). In indirect ELISA the antibody reacts with purified human mast cell tryptase (3). Antibody-binding to the mast cell tryptase does not affect enzyme activity (3). Periodate treatment of mast cell tryptase has no effect on antibody labeling, indicating that carbohydrate epitopes are not involved in antibody recognition. Nor is antibody recognition affected by the presence of heparin (3).

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Mast Cell Tryptase (Autostainer/Autostainer Plus)

Product Details

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