Glial fibrillary acidic protein (GFAP) is a 50 kDa intracytoplasmic filamentous protein that constitutes a portion of the cytoskeleton in astrocytes. With increasing astrocyte malignancy, there is a progressive loss of GFAP production. This antibody is a useful aid for the classification of astrocytoma and glioblastoma.
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GFAP isolated from cow spinal cord.
Purified immunoglobulin fraction of rabbit antiserum provided in liquid form. In 0.1 mol/L NaCl, 15 mmol/L NaN3, pH 7.2.
The antibody has been solid-phase absorbed with human and cow serum proteins. In crossed immunoelectrophoresis using 50 µL antibody per cm2 gel area, no reaction with 2 µL human plasma and 2 µL cow serum is observed. The antibody shows one distinct precipitate (GFAP) with cow brain extract. Staining: Coomassie Brilliant Blue.
In indirect ELISA, the antibody shows no reaction with human plasma and cow serum.
GFAP shows 90-95% homology between species (5), and as demonstrated by immunohistochemistry, the antibody reacts strongly with human GFAP.
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.