Brain

Glial Fibrillary Acidic Protein (Autostainer Link 48)

Clone Polyclonal

Glial fibrillary acidic protein (GFAP) is a 50 kDa intracytoplasmic filamentous protein that constitutes a portion of the cytoskeleton in astrocytes. With increasing astrocyte malignancy, there is a progressive loss of GFAP production. This antibody is a useful aid for the classification of astrocytoma and glioblastoma.

Polyclonal Rabbit Anti-

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	Polyclonal
Code Number	IR524
Immunogen	GFAP isolated from cow spinal cord.
Reagent Provided	Ready-to-use polyclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Rabbit Anti-
Specificity	The antibody has been solid-phase absorbed with human and cow serum proteins. In crossed immunoelectrophoresis using 50 µL antibody per cm² gel area, no reaction with 2 µL human plasma and 2 µL cow serum is observed. The antibody shows one distinct precipitate (GFAP) with cow brain extract. Staining: Coomassie Brilliant Blue. In indirect ELISA, the antibody shows no reaction with human plasma and cow serum. GFAP shows 90-95% homology between species (5), and as demonstrated by immunohistochemistry, the antibody reacts strongly with human GFAP.

Featured References

Product Description References: 1. Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 2000,25:1439-51.

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