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ERG (Ets-Related Gene) (Dako Omnis)

Prostate adenocarcinoma

ERG (Ets-Related Gene) (Dako Omnis)

Clone EP111

Ets-related gene (ERG) product is a ~41 kDa nuclear protein functioning as a DNA-binding transcriptional regulator that belongs to the erythroblast transformation-specific (ETS) family of transcription factors. In prostate cancer, ERG has most frequently been shown as a fusion protein with transmembrane protease, serine 2 (TMPRSS2), where a deletion between the TMPRSS2 and ERG genes causes the ERG gene to come under the control of the androgen-responsive promoter elements of TMPRSS2.

This antibody is a useful aid for the classification of prostate adenocarcinoma (1, 2). Furthermore, ERG may also be a useful aid for classification of prostatic intraepithelial neoplasia (PIN) and vascular tumors.

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