E (epithelial)-cadherin is a 120 kDa transmembrane cell adhesion molecule. It has a significant function in intercellular adhesion of epithelial cells, the establishment of epithelial polarization, glandular differentiation and stratification. Down-regulation of E-cadherin expression has been observed in a number of carcinomas and is usually associated with advanced stage and progression. The antibody is a useful aid for classification of ductal breast carcinomas.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
NCH-38
Code Number
IR059
Immunogen
E-cadherin (uvomorulin) recombinant protein (4). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
Solutions
Autostainer Link 48
Species
Mouse Anti-Human
Specificity
Anti-E-cadherin, NCH-38 recognizes the 120 kDa mature form and 82 kDa fragment of E-cadherin in Western blots of A431 cells lysates (4). See package insert for reference(s).