Labels smooth and striated muscle cells. The antibody works on paraffin-embedded material without pretreament with proteolytic enzymes. Anti-Desmin, clone D33, is a useful aid for classification of tumors of uncertain origin.
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Optimized for immunohistochemistry (IHC) with validated protocols
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Desmin purified from human muscle.
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN3.
In Western blotting of cytoskeletal preparations of MCF-7 cells, SCC-4 cells RT-112 cells, skin epidermis, primary culture of renal carcinoma cells, leiomyoma, fetal heart, and crude extract from human white matter of brain, the antibody labels only a ~53 kDa band in the leiomyoma and fetal heart preparations, proving the reactivity with desmin, and demonstrating the absence of reactivity with other types of intermediate filaments tested (7). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.