Cytomegalovirus Antibody (Concentrate)

Features

Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years’ experience ensuring quality and innovation in antibodies and reagents

Specifications


Application	Frozen Formalin Enzyme
Clone	CCH2 + DDG9
Code Number	M0854
Immunogen	Crude cell lysates from cytomegalovirus strain Ad169-infected human embryonic fibroblasts (3). See package insert for reference(s).
Isotype	IgG2a, kappa and IgG1, kappa
Reagent Provided	A mixture of two monoclonal mouse antibodies provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN₃.
Solutions	Concentrate
Species	Mouse Anti-
Specificity	Antibody CCH2 reacts with an early nuclear protein identical with the non-structural DNA-binding protein p52 (7). More than 200 human CMV isolates have been successfully typed by this antibody which, therefore, seems to recognize an epitope which is highly conserved among HCMV strains (3, 4). Antibody DDG9 reacts with an immediate early nuclear protein of about 76 kDa (3). For both antibodies, the reactivity persists also at later stages during the HCMV infection where the localisation is less distinctly nuclear and appears to be in the cytoplasm. Laser confocal microscopy, however, shows that the reaction is limited to the nuclear membrane (3). The antibodies do not cross-react with adenovirus, herpes simplex virus, and varicella zoster virus (3). See package insert for reference(s).

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Literature

Technical Overviews

Immunohistochemical Staining Methods - Education Guide, Sixth Edition

The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.

Technical Overviews
English
30 Nov 2021
27.05 MB
PDF

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Featured References

Product Description References: 1. Niedobitek G, Finn T, Herbst H, et al. Detection of cytomegalovirus by in situ hybridisation and immunohistochemistry using the new monoclonal antibody CCH2: a comparison of methods. J Clin Pathol 1988,41:1005-9.
2. Wirgart BZ, Landqvist M, Hökeberg I, et al. Early detection of cytomegalovirus in cell culture by a new monoclonal antibody, CCH2. J Virol Methods 1990,27:211-20.

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Cytomegalovirus (Concentrate)

Product Details

Immunohistochemical Staining Methods - Education Guide, Sixth Edition

View supported Instructions For Use documents

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