Reacts strongly with cytokeratins 5 and 6 and weakly with cytokeratin 4. The antibody does not cross-react with cytokeratins 1, 7, 8, 10, 13, 14, 18 and 19. It labels mesothelioma, and epithelial basal cells in prostate and tonsil. No reactivity with other mesodermally derived tissues, such as muscle and connective tissues, has been observed. The antibody is a useful aid for classification of epithelioid mesotheliomas.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
HIER
Clone
D5/16 B4
Code Number
M7237
Immunogen
Isolated cytokeratin 5.
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as purified IgG from ascitic fluid. In 0.05 mol/L Tris-HCl, 15 mmol/L NaN3, 1% bovine serum albumin, pH 7.2.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
In Western blotting of cytoskeletal preparations of epidermis and non-keratinizing epithelium, the antibody labels cytokeratin 5. It also labels cytokeratin 6 and weakly labels cytokeratin 4. No cross-reaction with cytokeratins 1, 7, 8, 10, 13/14, 18 and 19 has been found.
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.