Reacts with the 46 kDa protein corresponding to cytokeratin 20. The antibody is a useful aid for classification of adenocarcinomas of the colon, mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas, adenocarcinomas of the stomach, bile system and pancreas. Results also aid in the classification of most squamous cell carcinomas and most adenocarcinomas from other sites (breast, endometrium, lung, prostate), non-mucinous tumors of the ovary, and small-cell lung carcinomas as these may be negative.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
Enzyme/HIER
Clone
Ks20.8
Code Number
M7019
Immunogen
CK20 isolated by SDS-PAGE from cytoskeletal material obtained from human duodenal mucosa (1). See package insert for reference(s).
Isotype
IgG2a, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as purified mouse IgG from ascitic fluid. In 0.05 mol/L Tris-HCl, 15 mmol/L NaN3, 1 % bovine serum albumin, pH 7.2.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
Anti-Human CK 20, Clone Ks .20.8, labels a 46 kDa polypeptide corresponding to CK 20 in Western immunoblotting of SDS-PAGE-separated cytoskeletal proteins from human duodenal mucosa (1). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.
1. Moll R, Löwe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. Am J Pathol 1992,140:427-47. 2. Harnden P, Mahmood N, Southgate J. Expression of cytokeratin 20 redefines urothelial papillomas of the bladder. Lancet 1999,353:974-7. 3. Chu P, Wu W, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol 2000,13:962-72.